Cross-sectional and longitudinal determinents of SHBG in a cohort of community- dwelling men

madman

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http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0200078&type=printable



Conclusion:

- our study has confirmed an age-related rise in circulating SHBG in men, beginning from middle-age

- beyond this gradual increase, reduced SHBG levels largely reflects obesity, particularly men with a substantial or predominant visceral fat component with associated metabolic consequences

- we suggest that variation in SHBG reflects de novo lipogenesis within the liver that occurs in the context of insulin resistance

- the observed positive relationship between thyroid hormones and SHBG levels suggest that thyroid hormone may modulate circulating SHBG, either directly or indirectly

- high circulating sex steroids are associated with higher SHBG levels reflecting the direct effect of sex steroids
 

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