madman
Super Moderator
http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0200078&type=printable
Conclusion:
- our study has confirmed an age-related rise in circulating SHBG in men, beginning from middle-age
- beyond this gradual increase, reduced SHBG levels largely reflects obesity, particularly men with a substantial or predominant visceral fat component with associated metabolic consequences
- we suggest that variation in SHBG reflects de novo lipogenesis within the liver that occurs in the context of insulin resistance
- the observed positive relationship between thyroid hormones and SHBG levels suggest that thyroid hormone may modulate circulating SHBG, either directly or indirectly
- high circulating sex steroids are associated with higher SHBG levels reflecting the direct effect of sex steroids
Conclusion:
- our study has confirmed an age-related rise in circulating SHBG in men, beginning from middle-age
- beyond this gradual increase, reduced SHBG levels largely reflects obesity, particularly men with a substantial or predominant visceral fat component with associated metabolic consequences
- we suggest that variation in SHBG reflects de novo lipogenesis within the liver that occurs in the context of insulin resistance
- the observed positive relationship between thyroid hormones and SHBG levels suggest that thyroid hormone may modulate circulating SHBG, either directly or indirectly
- high circulating sex steroids are associated with higher SHBG levels reflecting the direct effect of sex steroids
