Comprehensive post with detailed bloodwork I need help /High T3 / High Cholestrol / High E2

[1Dani]

Hi all,
Would love some input on my bloodtests.
Sorry about my English not a native speaker.


Ive switched from gel to injection after experiencing what I feel has been high peaks on gels and lots of negative stuff like urination frequency, pressure in the pelvis etc, on / off libido/erections.

I experience on / off extreme urination frequency on gels and at the start of injections.
Some nights I wake up 3-4 times to pee, I do think this is because my bladder is almost trained to pee all the time after years on gels so it cant difference from day/ night any more.
I do not think its prostate on injections, I do think on gels the prostatet got irritated and that cause the pressure feeling in the pelvic this is mostly(99%) gone on injections but Ive only been on injections for little over 6weeks.

This is my dosage regime
50mg test e every 3,5day
e2 is (S-Østradiol-17beta ) on the bloodtests .
Age 38
Normal built and weight is good


Bloodtest on day 3,5 before injection that day


And here is day after dosing 50mg



SHBG over the years


E2 over the years


T3 over the years, times it peak or T4 has peaked is the worse times with urination frequency.


Free testestron only 0,383% ?


What I am worried about is 3 things my cholesterol , my e2 (S-Østradiol-17beta ) and my T3 level.

I really dont feel like its 1000 ng/dl I am getting but I think gels runined this for me as I think gel peaked me atleast around 1000-1100 for then drop very fast causing distress to my hormonal system. I was on 1 1/2 schachet of testogel, but mostly I only did 1.

In regards to cholestrol you can see a time line for the 3 big ones here, its been bad before but as person with extreme high levels of Lipoprotein A / little l / Lpa this scares me.





Is T3 causing my urination frequency ? Should I not worry that much about E2 ? Can stress push my cholestrol into a bad place ? Is my T levels to high ? Split dosing into every other day ?
I will begin supplement with Citrus bergamont and I am considering Ezetimibe.

This post is all over the place but I hope some members that have knowledge will take the time to read and help me.

 

[Systemlord]

I experience on / off extreme urination frequency on gels and at the start of injections.

I experienced the same on Jatenzo (oral T) 1-2 hours after my dosing. It's a longer than usual emptying of the bladder.

I have never had prostate issues.

T3 over the years, times it peak or T4 has peaked is the worse times with urination frequency.

T3 isn't very useful by itself, the free hormones (fT3), the most potent thyroid hormone is where the rubber meets the road.

For all we know your conversion of T4 to fT3 isn't high, leading to midrange fT3 levels.

 

[Systemlord]

I do think on gels the prostatet got irritated and that cause the pressure feeling in the pelvic

Gels have the advantage of producing higher DHT levels versus any other formulation of TRT, which can affect the prostate, especially in older men.

The injections produce the lowest DHT levels of any TRT option with Jatenzo coming in second place to topicals.

 

[1Dani]

I experienced the same on Jatenzo (oral T) 1-2 hours after my dosing. It's a longer than usual emptying of the bladder.

I have never had prostate issues.


T3 isn't very useful by itself, the free hormones (fT3), the most potent thyroid hormone is where the rubber meets the road.

For all we know your conversion of T4 to fT3 isn't high, leading to midrange fT3 levels.

My bladder goes empty fast if not I would consider prostate issues, my problem is that I go all the time and go full blast when I pee, its like my body dont want to hold water.

I posted also T4 and TSH levels, in Norway its very hard to get the "special" other test like ultra senstive e2 etc from your doctor as we have public healthcare.

 

[1Dani]

Gels have the advantage of producing higher DHT levels versus any other formulation of TRT, which can affect the prostate, especially in older men.

The injections produce the lowest DHT levels of any TRT option with Jatenzo coming in second place to topicals.

Tabs is the worst I tried but it was andriol when we had a testogel shortage.
I dont see DHT as a pro to be honest for myself after using gel.

 

[Cataceous]

I'm not sure which free testosterone calculator you used, but this implementation of the Vermeulen calculation says that free testosterone is 0.912 nMol/L (26 ng/dL), which is 2.6% of total. Keep in mind that the percent of total is not a very useful number.

It seems likely that some of your problems are a result of using a dose that's too high for you. Would it be feasible for you to increase your injection frequency to every other day? This would cut down peak serum levels. In addition, I would try dropping the total weekly dose by 25%, which would mean injecting 20 or 21 mg EOD. Allow at least 2-3 months for a fair evaluation.

Lower dosing should make absolute levels of estradiol more reasonable. However, you should monitor the estradiol/testosterone ratio. If it remains high and you continue to have problems then there are other things you might try. Lipids should improve somewhat on the lower dose. T3 may come down as well.

...
T3 isn't very useful by itself, the free hormones (fT3), the most potent thyroid hormone is where the rubber meets the road.
...

"fritt" means free. This might be deduced, but one could also ask Google Translate, or alternatively, pay attention to the units.

 

[1Dani]

I'm not sure which free testosterone calculator you used, but this implementation of the Vermeulen calculation says that free testosterone is 0.912 nMol/L (26 ng/dL), which is 2.6% of total. Keep in mind that the percent of total is not a very useful number.

It seems likely that some of your problems are a result of using a dose that's too high for you. Would it be feasible for you to increase your injection frequency to every other day? This would cut down peak serum levels. In addition, I would try dropping the total weekly dose by 25%, which would mean injecting 20 or 21 mg EOD. Allow at least 2-3 months for a fair evaluation.

Lower dosing should make absolute levels of estradiol more reasonable. However, you should monitor the estradiol/testosterone ratio. If it remains high and you continue to have problems then there are other things you might try. Lipids should improve somewhat on the lower dose. T3 may come down as well.

"fritt" means free. This might be deduced, but one could also ask Google Translate, or alternatively, pay attention to the units.

Thank you for taking a look at my bloodtests.
You think it would be any value of trying the same dose just split into EOD?
I might just try 80mg pr week dosing EOD but not sure how to calculate that into a 7day week. Maybe calculate from a 2week timeframe ?

 

[Cataceous]

...
You think it would be any value of trying the same dose just split into EOD?
...

I expect this would help a little, but not enough to be worth a separate experiment.

...
I might just try 80mg pr week dosing EOD but not sure how to calculate that into a 7day week. Maybe calculate from a 2week timeframe ?

80 mg/week / 3.5 EODs/week = 23 mg/EOD
75 mg/week / 3.5 EODs/week = 21 mg/EOD

Don't get trapped in the more-is-better mindset. Over time I've reduced TRT from 100 mg/week to the equivalent of 44 mg/week. Overall I do better on the lower dose. The average healthy young man naturally produces testosterone equivalent to about 65 mg/week of testosterone cypionate. Arguably half of the guys taking more than this for TRT are operating above their healthy natural levels.

Take a spin through my collection of anecdotes about lowering the dose:

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Anyone combine injections and cream? How do you feel?

I’m a long term TRT patient, 39 years old. I’ve been on cypionate and inject a total of 154mg weekly in EOD subQ shots of 44mg each. I have been doing some thinking about the potential benefit of keeping dosing the same but experimenting with using a low cypionate base around 80-100mg weekly...

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Anyone combine injections and cream? How do you feel?

Interesting anecdote. I’m curious what what your SHBG and current protocol are? @JoeMatts im curious for this as well

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[Systemlord]

fritt" means free.

That might change the entire direction of the discussion.

 

[1Dani]

I expect this would help a little, but not enough to be worth a separate experiment.

80 mg/week / 3.5 EODs/week = 23 mg/EOD
75 mg/week / 3.5 EODs/week = 21 mg/EOD

Don't get trapped in the more-is-better mindset. Over time I've reduced TRT from 100 mg/week to the equivalent of 44 mg/week. Overall I do better on the lower dose. The average healthy young man naturally produces testosterone equivalent to about 65 mg/week of testosterone cypionate. Arguably half of the guys taking more than this for TRT are operating above their healthy natural levels.

Take a spin through my collection of anecdotes about lowering the dose:

I got all the bad stuff back going to 0,1ml hope it begins solves it self by the next dose because this was depressing. Worst is the pressure feeling in the pelic area is back with a vengence from hell.
Last week on 0,2ml was great to be honest, only concern was the bloodwork.
TRT seems like a chess game sometimes.

 

[1Dani]

I'm not sure which free testosterone calculator you used, but this implementation of the Vermeulen calculation says that free testosterone is 0.912 nMol/L (26 ng/dL), which is 2.6% of total. Keep in mind that the percent of total is not a very useful number.

It seems likely that some of your problems are a result of using a dose that's too high for you. Would it be feasible for you to increase your injection frequency to every other day? This would cut down peak serum levels. In addition, I would try dropping the total weekly dose by 25%, which would mean injecting 20 or 21 mg EOD. Allow at least 2-3 months for a fair evaluation.

Lower dosing should make absolute levels of estradiol more reasonable. However, you should monitor the estradiol/testosterone ratio. If it remains high and you continue to have problems then there are other things you might try. Lipids should improve somewhat on the lower dose. T3 may come down as well.

"fritt" means free. This might be deduced, but one could also ask Google Translate, or alternatively, pay attention to the units.

Ive tried EOD feelt awfull, then I let one day extra between due to 14day sceduel Ive not feelt this good since I started on injections from gels.
But I am unsure why ?
Pressure in pelvis almost gone, no urination at night, so for me its obevious testosteron makes some bad changes in the pelvis area if its bladder or prostat I dont know.
Any advice from the experineced people in here ?

Going down to 75-80mg pr week with EOD injection made every symptoms worse, so bad that I know I cant handle it for 6weeks.