Clomiphene Protocol

penguinwoolf

New Member
Hi all,

Yesterday I started a low-dose clomid protocol (12.5mg twice weekly // EOD). I was prescribed 25mg EOD by the Doc, but I am overly-cautious by nature...

Baseline blood are below

Blood Draw 26th July (Control Test)

TESTOSTERONE --------------------------------10.2 nmol/L 7.60 - 31.40
FREE-TESTOSTERONE(CALCULATED) ---------*0.16 nmol/L 0.30 - 1.00
17-BETA OESTRADIOL --------------------------50.7 pmol/L 0.00 - 191.99
SEX HORMONE BINDING GLOB -----------------47.68 nmol/L 16.00 - 55.00


Blood Draw 11th September (6 weeks Plant Based Diet)

TESTOSTERONE ---------------------------------14.7 nmol/L 7.60 - 31.40
FREE-TESTOSTERONE(CALCULATED) -----------*0.2 nmol/L 0.30 - 1.00
SEX HORMONE BINDING GLOB ------------------*61.2 nmol/L 16.00 - 55.00
FREE ANDROGEN INDEX --------------------------24.02 Ratio 24.00 - 104.00
17-BETA OESTRADIOL ----------------------------34.4 pmol/L 0.00 - 191.99
D.H.E.A. SULPHATE -------------------------------5.700 umol/L 0.44 - 13.40
FOLLICLE STIM. HORMONE -----------------------4.03 IU/L 1.50 - 12.40
LUTEINISING HORMONE --------------------------4.79 IU/L 1.70 - 8.60


I appreciate it may seem counter-intuitive to start a Clomid treatment based on my already high SHBG. These are my reasons:

1) My FT levels have always been abnormally low, with the exception of a Vegan experiment I ran last year. Although my SHBG rose high, my Total Testosterone shot up to compensate, creating a higher FT than I have ever had while Omnivore

2) I have seen significant benefits on my mood since switching Plant Based, which is equally important to me as other symptoms

3) I have not yet seen a successful protocol which has reliably decreased SHBG to the level I would need it to decrease to in order to get decent FT. I figure I might as well see it as ally rather than enemy and not worry about boosting it, with the hope that my TT and FT rise in order to compensate

4) I'm 26, so I figure to go with the least invasive option first and take it from there

Will update with changes in symptoms and post new results as and when.

Any thoughts or questions, just let me know!

Penguin
 
Last edited by a moderator:
Given that SHBG is what it is, I would say that it's unlikely you'll overcome the SHBG/Free T issue as typically guys on Cyp that run that high of SHBG they have to get TT way up there, over 1000 at least just to free up some T for Free T. Will be interesting to see how this low dose works for you, concentrate on feeling better and not so much the numbers. You might find that you feel good and that's key.
 
Hi all,
Yesterday I started a low-dose clomid protocol (12.5mg twice weekly // EOD). I was prescribed 25mg EOD by the Doc, but I am overly-cautious by nature...

So you changed the bad protocol from your doc of 25mg EOD to a safer protocol of twice a week 12.5mg, is that correct?

I've started a protocol too and did something similar. I'm doing twice a week 6.25mg. Been awesome so far, 2 weeks on it. My case is in this thread if you wanna give some input:

https://www.excelmale.com/forum/showthread.php?11878-On-a-Clomid-Protocol
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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