Clomid Safe for Hashimotos?

[LakeGuy81]

Hey guys, I'm a 37 y/o male who just had a consult with Defy. I knew my T would be low from prior testing, but my labs also indicated Hashimotos's disease with elevated antibodies. TPO was 75 IU/ml with a range of 0-34 and my Thyroglobulin Antibody was 17.3 with a range of 0.0-0.9. I am heavily reasearching the Hashi's right now and plan to hopefully manage them through a possible gluten-free diet and supplements like selenium and Vitamin D. Other thyroid numbers looked to be in range (for now):

TSH: 2.65 (.450-4.500)
T3 Free: 3.8 (2.0-4.4)
T4 Free: 1.58 (.82-1.77)
Reverse T3: 19.6 (9.2-24.1)

Defy is basically taking a "wait and see" approach to the Antibodies, which is standard practice as I don't believe it's a treatable thyroid condition for them at this stage. They are giving me the option of Clomid or Test Cream (my request), I have done injections in the past and will do them again if needed, but I want to try some different approaches first. Other labs below:

Total T: 217 (264-916)
Free T: 8.5 (8.7-27.1)
E2 Sensitive: 19.3 (8.0-35.0)
SHGB: 24.5 (16.5-55.9)
LH: 2.9 (1.7-8.6)
Prolactin: 6.3 (4.0-15.2)
DHEA-S: 423.9 (102.6-416.3)

Questions: I've been researching the relation to Clomid and Thyroid Antibodies, and I'm seeing some negative talk about mixing the two on the female pregnancy forums but I can't find any men with Hashi's who've tried Clomid? Anyone have experience with this? My plan with Defy is to try Clomid first, see if I react, and then we can always fall back on the T later. Any insight or help here would be appreciated, I just don't want to screw up my thyroid anymore than it already is!

 

[Vince]

I definitely would try clomid, you really don't have nothing to lose. Is Defy Medical giving you any thyroid meds.

Your estrogen level is high compared to your testosterone level. So I'm sure any treatment you have will cause you to have elevated E2 levels.

 

[LakeGuy81]

I definitely would try clomid, you really don't have nothing to lose. Is Defy Medical giving you any thyroid meds.

Your estrogen level is high compared to your testosterone level. So I'm sure any treatment you have will cause you to have elevated E2 levels.

No, they didn’t give me any thyroid meds because the main #’s, not antibody, looked OK. What do you think there? I’ve been researching for 2-3 days now on whether I should address the thyroid before TRT?

 

[Vince]

No, they didn’t give me any thyroid meds because the main #’s, not antibody, looked OK. What do you think there? I’ve been researching for 2-3 days now on whether I should address the thyroid before TRT?

I would look for a very good Endocrinology doctor or Thyroid specialist. I would also read the stop the thyroid madness book. My two cents would be treat your thyroid first and then consider trt. Maybe your thyroid issues would solve your low testosterone or maybe not. You'll never know if you don't take care of your thyroid first.

 

[Vince]

Access Pass to My Thyroid Documentary - Dr. Izabella Wentz

 

[LakeGuy81]

I would look for a very good Endocrinology doctor or Thyroid specialist. I would also read the stop the thyroid madness book. My two cents would be treat your thyroid first and then consider trt. Maybe your thyroid issues would solve your low testosterone or maybe not. You'll never know if you don't take care of your thyroid first.

Thanks Vince. I'm in a bad spot right now and feel like I'm fighting a two-front war with low T and the Hashimotos. Girlfriend is getting really impatient on the low T symptoms, and frankly, I am too. As my other thyroid levels were decent, 95% of what I'm reading on Hashi's is that you really can't "treat it" all you can do is gluten free diet and some other things to stop inflammation triggers. Even with that, it could take 3-6 months before I see any changes in the Hashi's, and that would be another 3-6 months of suffering with low T.

Anyone else on here started TRT with high thyroid antibodies? Did it make your antibodies worse? Make them better?

 

[Vince Carter]

Don't overlook your reverse T3, >15 indicates pooling which is the T3 not entering the cells or being usable. Typical treatment is to have T3 prescribed which should push the reverse T3, down and enable that to be usable by the cells.

 

[Vince Carter]

Poeple that do well on Clomid are usually called Unicorns for good reason though most are overdosed at 25-50mg/D. I don't recommend it other than to ensure that it's not overdosed...25mg/D is too much, 12.5mg/D is better if not 12.5mg EOD. Clomid tends to drive up Estrogen, and SHBG, both of which will work against the end goal of raising Test.

 

[Vince]

Don't overlook your reverse T3, >15 indicates pooling which is the T3 not entering the cells or being usable. Typical treatment is to have T3 prescribed which should push the reverse T3, down and enable that to be usable by the cells.

With hashimoto's, I would plan on going with no grains and low carb. I have hypothyroidism and over seven years ago I went grain-free and low carb. I am being tested for hashimoto's on June 4th. I have heard that 85% of the people that have hypothyroidism probably has hashimoto's, even if they have tested negative for it.