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Raynaud's Disease, a rheumatological disorder, is the sudden constriction of blood vessels in the extremities, particularly in the hands, causing sharp pain, blanching, loss of sensation, and - in extreme cases - tissue destruction. More often seen in northern climates, and more prevalent in men, it is a disorder that is managed, not cured. Studies suggest that Cialis (Tadalafil) is an effective adjuctive therapy for managing Raynaud's.
Conclusion. Tadalafil as add-on therapy improves symptoms of RP, heals and prevents new DUs and improves QoL in patients with resistant secondary RP.
"Efficacy of tadalafil in secondary Raynaud’s phenomenon resistant to vasodilator therapy: a double-blind randomized cross-over trial," Rheumatology December 2010, https://academic.oup.com/rheumatology/article/49/12/2420/1791021
- Patients having four or more Raynaud's attacks per week despite being on vasodilators were randomized to receive either placebo or tadalafil (20 mg) on alternate days as add-on therapy to their current vasodilators for 6 weeks.
- Twenty-four of 25 recruited patients completed the study. All the patients were receiving calcium channel blockers and in addition 18 were receiving other vasodilators.
- During tadalafil therapy significant improvement in mean daily frequency, mean daily duration of RP and mean daily RCS were observed as compared with baseline and placebo.
- All the 24 digital lesions healed during tadalafil therapy as compared with 3/13 during the placebo treatment (P < 0.0001).
- No serious adverse event was observed.
Conclusion. Tadalafil as add-on therapy improves symptoms of RP, heals and prevents new DUs and improves QoL in patients with resistant secondary RP.
"Efficacy of tadalafil in secondary Raynaud’s phenomenon resistant to vasodilator therapy: a double-blind randomized cross-over trial," Rheumatology December 2010, https://academic.oup.com/rheumatology/article/49/12/2420/1791021
