Choline associated hypersexuality in a 79-year-old man

[Biobro]

Choline associated hypersexuality in a 79-year-old man - PubMed

Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a...

pubmed.ncbi.nlm.nih.gov

Choline associated hypersexuality in a 79-year-old man

Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a dietary supplement in different diseases. This report was aimed at considering choline intake as a possible cause of iatrogenic hypersexuality. After an evaluation, a 79-year-old man affected by memory loss was diagnosed with mild cognitive impairment and treated with oral choline. After 6 weeks of regular choline assumption, the patient showed a pathological increase in libido with sexual urges. As choline was withdrawn, the hypersexuality disappeared within 5 days. Since hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic pathway, this should be considered when treating and counselling patients with inappropriate sexual behavior.

 

[Jerajera]

Choline about to come off the shelves faster than toilet paper during Covid.

 

[davidandrade]

Choline associated hypersexuality in a 79-year-old man - PubMed

Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a...

pubmed.ncbi.nlm.nih.gov

Choline associated hypersexuality in a 79-year-old man

Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a dietary supplement in different diseases. This report was aimed at considering choline intake as a possible cause of iatrogenic hypersexuality. After an evaluation, a 79-year-old man affected by memory loss was diagnosed with mild cognitive impairment and treated with oral choline. After 6 weeks of regular choline assumption, the patient showed a pathological increase in libido with sexual urges. As choline was withdrawn, the hypersexuality disappeared within 5 days. Since hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic pathway, this should be considered when treating and counselling patients with inappropriate sexual behavior.

Wonder how many mgs per day and what form of choline?

 

[KevinL]

Choline associated hypersexuality in a 79-year-old man - PubMed

Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a...

pubmed.ncbi.nlm.nih.gov

Choline associated hypersexuality in a 79-year-old man

Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a dietary supplement in different diseases. This report was aimed at considering choline intake as a possible cause of iatrogenic hypersexuality. After an evaluation, a 79-year-old man affected by memory loss was diagnosed with mild cognitive impairment and treated with oral choline. After 6 weeks of regular choline assumption, the patient showed a pathological increase in libido with sexual urges. As choline was withdrawn, the hypersexuality disappeared within 5 days. Since hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic pathway, this should be considered when treating and counselling patients with inappropriate sexual behavior.

I have taken up to 3grams of choline with inositol for a month. I do this once a yr for liver health and never experienced anything like this.

 

[Biobro]

Wonder how many mgs per day and what form of choline?

”oral choline supplementation (i.e., cho- line alphoscerate, a precursor of the phosphatidylcholine) was prescribed at a dosage of 1200 mg/day.
After 6 weeks of regular choline ingestion, the patient showed a significant increase in libido with sexual urges, even in inap- propriate places. His wife, a healthy 70-year-old woman, said that her husband had unexpectedly changed his sexual behavior: they usually had regular sexual intercourse no more than once a month, but, in the last weeks, he wanted to engage her in sexual activity at least three times a day and often asked her for oral sex.
Moreover, the patient was very annoyed and nervous when his wife refused sexual contacts; thus, he started masturbating ‘‘to alleviate his psychological discomfort.’’
Interestingly, while on choline, the patient and his wife reported a significant improvement in erectile function. Because of this abnormal sexual behavior, choline was withdrawn and hypersexuality receded after about 5 days.
Before choline discontinuation, the patient’s sex hormone levels, including total (7 ng/ml) and free testosterone (0.14 ng/ ml), were within the normal range. Intriguingly, since the patient was ‘‘proud’’ of his sexual potency while on choline, he spontaneously and secretively ingested oral choline for about another month with a consequent hypersexuality.
The patient resumed his ‘‘normal’’ sexual behavior after complete withdrawal of choline intake.”

Horny and proud grandpa!

 

[BadassBlues]

I would like to know what form he was taking. I have used CDP Choline in the past for mental clarity and mood. I have not tried Choline directly.

Choline is neurotransmitter enhancer and acts on dopamine. It's easy to see why he had that reaction to it. Sadly, it won't do that for everyone though. Still... it's worth a try

 

[davidandrade]

”oral choline supplementation (i.e., cho- line alphoscerate, a precursor of the phosphatidylcholine) was prescribed at a dosage of 1200 mg/day.
After 6 weeks of regular choline ingestion, the patient showed a significant increase in libido with sexual urges, even in inap- propriate places. His wife, a healthy 70-year-old woman, said that her husband had unexpectedly changed his sexual behavior: they usually had regular sexual intercourse no more than once a month, but, in the last weeks, he wanted to engage her in sexual activity at least three times a day and often asked her for oral sex.
Moreover, the patient was very annoyed and nervous when his wife refused sexual contacts; thus, he started masturbating ‘‘to alleviate his psychological discomfort.’’
Interestingly, while on choline, the patient and his wife reported a significant improvement in erectile function. Because of this abnormal sexual behavior, choline was withdrawn and hypersexuality receded after about 5 days.
Before choline discontinuation, the patient’s sex hormone levels, including total (7 ng/ml) and free testosterone (0.14 ng/ ml), were within the normal range. Intriguingly, since the patient was ‘‘proud’’ of his sexual potency while on choline, he spontaneously and secretively ingested oral choline for about another month with a consequent hypersexuality.
The patient resumed his ‘‘normal’’ sexual behavior after complete withdrawal of choline intake.”

Horny and proud grandpa!

Oh got it! This is Alpha GPC as I know it. It supposed to be the best choline supplement because it crosses the blood brain barrier easily. I'm no grandpa but could definitely use some help in the libido department so going to give this a try haha!

 

[BadassBlues]

Oh got it! This is Alpha GPC as I know it. It supposed to be the best choline supplement because it crosses the blood brain barrier easily. I'm no grandpa but could definitely use some help in the libido department so going to give this a try haha!

Not exactly the same, but the end results are similar.

What’s the Difference? Comparing the Benefits of Citicoline and Alpha GPC

Compare the benefits of Citicoline and Alpha GPC, two popular nootropic compounds, and discover their unique advantages for cognitive enhancement

www.qualialife.com

DIFFERENCES BETWEEN CITICOLINE AND ALPHA GPC BENEFITS​

Now that you know what each compound is and what benefits each could provide, you may wonder what the differences are between them. At first glance, both appear to do the same thing in regard to overall brain function and mental acuity. There are, however, some differences to how those benefits are achieved. For example, alpha GPC and citicoline have different metabolism processes. As alpha GPC breaks down, acetylcholine is released as a byproduct, where as citicoline serves as a derivative of the same chemical.

Alpha GPC may also have a number of interesting side effects that citicoline doesn’t have. Taking alpha GPC could lead to improved vitality and increased strength as it helps muscles recover after exercise. Alpha GPC may also increase the production of growth hormone in the human body while at the same time acting as something of a weak stimulant.

Citicoline, on the other hand, may have other benefits that alpha GPC does not. One of the most talked about is the possibility of amplifying the impact of other nootropics. For this reason, many people consider citicoline a definite inclusion in any supplementation program.

 

[davidandrade]

Not exactly the same, but the end results are similar.

What’s the Difference? Comparing the Benefits of Citicoline and Alpha GPC

Compare the benefits of Citicoline and Alpha GPC, two popular nootropic compounds, and discover their unique advantages for cognitive enhancement

www.qualialife.com

DIFFERENCES BETWEEN CITICOLINE AND ALPHA GPC BENEFITS​

Now that you know what each compound is and what benefits each could provide, you may wonder what the differences are between them. At first glance, both appear to do the same thing in regard to overall brain function and mental acuity. There are, however, some differences to how those benefits are achieved. For example, alpha GPC and citicoline have different metabolism processes. As alpha GPC breaks down, acetylcholine is released as a byproduct, where as citicoline serves as a derivative of the same chemical.

Alpha GPC may also have a number of interesting side effects that citicoline doesn’t have. Taking alpha GPC could lead to improved vitality and increased strength as it helps muscles recover after exercise. Alpha GPC may also increase the production of growth hormone in the human body while at the same time acting as something of a weak stimulant.

Citicoline, on the other hand, may have other benefits that alpha GPC does not. One of the most talked about is the possibility of amplifying the impact of other nootropics. For this reason, many people consider citicoline a definite inclusion in any supplementation program.

Oh wait, so it was Citicoline used in the study and not Alpha GPC?

 

[BadassBlues]

Oh wait, so it was Citicoline used in the study and not Alpha GPC?

My bad, it was Alpha GPC that was used. I missed that at first read.

 

[Biobro]

Yes, alpha GPC. Its little bit pricey if u use it as same dosage than in the study 1200mg/day,
but if u buy it as a bulk its cheap.
I actually ordered myself. I have pfs/pssd, so anything that improves libido or is associated to hypersexuality etc is welcome.

https://www.bulksupplements.com/products/alpha-gpc-l-alpha-glycerylphosphorylcholine

 

[Systemlord]

With my extreme sensitivities to certain substances, I’m going to give this a try.

 

[BadassBlues]

I'm pretty sure Amazon is wondering what the Hell is going on after this post... I'm sure a hundred guys have just ordered this...LOL. I am one of them

 

[FunkOdyssey]

Yes, alpha GPC. Its little bit pricey if u use it as same dosage than in the study 1200mg/day,
but if u buy it as a bulk its cheap.
I actually ordered myself. I have pfs/pssd, so anything that improves libido or is associated to hypersexuality etc is welcome.

https://www.bulksupplements.com/products/alpha-gpc-l-alpha-glycerylphosphorylcholine

Just a warning that choline can cause or worsen depression in some susceptible individuals (like myself). There is a cholinergic theory of depression that was dominant for awhile, which posited that an imbalance of neurotransmitters, favoring acetylcholine, is a primary cause of depression. This was supported by the fact that certain anticholinergic medications were known to boost mood or cause euphoria, while acetylcholinesterase inhibitors often cause depression. Obviously, we know now that this is not the whole story of depression, but acetylcholine remains an important and usually unhelpful factor in mood disorders.

Cholinergic Regulation of Mood: From Basic and Clinical Studies to Emerging Therapeutics - PMC

Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems ...

www.ncbi.nlm.nih.gov

 

[Biobro]

Just a warning that choline can cause or worsen depression in some susceptible individuals (like myself). There is a cholinergic theory of depression that was dominant for awhile, which posited that an imbalance of neurotransmitters, favoring acetylcholine, is a primary cause of depression. This was supported by the fact that certain anticholinergic medications were known to boost mood or cause euphoria, while acetylcholinesterase inhibitors often cause depression. Obviously, we know now that this is not the whole story of depression, but acetylcholine remains an important and usually unhelpful factor in mood disorders.

Cholinergic Regulation of Mood: From Basic and Clinical Studies to Emerging Therapeutics - PMC

Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems ...

www.ncbi.nlm.nih.gov

Yes. everyone is different. Choline can be holy grail for someone(like the 79- years old grandpa) and worst nightmare to someone. Depending on your own neurotransmitter balance, individual response, etc etc.


Here is good info in general about choline and acethylcholine:

How To Increase Acetylcholine Naturally (Hidden Secrets)​

Choline Increases Heart Disease Risk?! (Research Exposed) (Choline bitartrate)​

article on acetylcholine which describes symptoms of high and low acetylcholine. Info from about what can cause it to be high or low and what supplements can be used to block or boost it:

The high acetylcholine syndrome » TESTONATION

Could acetylcholine be the root of your mental or physical symptoms? Acetylcholine is the primary neurotransmitter of the parasympathetic nervous systems, but is also involved with the sympathetic nervous system, such as assisting with muscle contraction, vasodilation to the skin and sweating...

testonation.com

Could acetylcholine be the root of your mental or physical symptoms?

Acetylcholine is the primary neurotransmitter of the parasympathetic nervous systems, but is also involved with the sympathetic nervous system, such as assisting with muscle contraction, vasodilation to the skin and sweating.

When acetylcholine levels are too high or unopposed, as during REM sleep, the skeletal muscles are under complete paralysis to prevent sudden movement during dreaming.

Acetylcholine is created by the enzyme choline acetyltransferase from choline and acetyl-CoA.

In the brain it is unlikely that choline acetyltransferase is saturated with either of its substrates, so that choline (and possibly acetyl-CoA) availability determines the rate of acetylcholine synthesis.

Acetylcholine is broken down by the enzyme acetylcholinesterase, which converts acetylcholine into choline and acetate. Choline can then be used for the synthesis of phospholipids, methylation, the recreation of acetylcholine, etc.

Acetylcholine plays an important role in arousal, attention, memory, motivation and muscle function. Lots of issues can occur either when in excess or when too low.

Here are a few mental signs of excess acetylcholine. Keep in mind, the low acetylcholine will sometimes have the opposite effect. For example, acetylcholine is needed for attention, so excess can cause hyperfocused rumination on (usually negative) thoughts, whereas too little could contribute to ADHD.

Acetylcholine in the brain:​

• Is low in dementia and possibly depersonalization as well.
• Reduces anhedonia by stimulating the release of glutamate and dopamine. In this study, knockdown of choline acetyltransferase in the rat habenula was sufficient to evoke anhedonia-like behavior (R). However, striatal acetylcholine, released during stress-induced CRH release (HPA axis stress response), decreases reward-seeking and contributes to anhedonia (R).
• Is involved in Alzheimer’s and Parkinson’s disease
• Is elevated in depression/suicide victims. Lowering acetylcholine, by either blocking its receptors or presynaptically activating M2/M4 mAChRs (which act as inhibitory autoreceptors), reduces glutamate release. Excess glutamate is implicated in depression. Nicotinic receptor antagonists are useful against depression and bipolar (R). Atropine, an anticholinergic, upregulates CRH receptors in the cerebral cortex and shows that excess acetylcholine can contribute to CRH insensitivity and lead to high CRH levels (R). Elevated CRH is also implicated in many neurological and mental disorders, such as depression.
• Increases symptoms of anxiety and reactivity to stress (R). Stressors that would be ignored over time by someone with lower levels of acetylcholine signaling might be paid more attention to and provoke a physiological response in a depressed individual with elevated acetylcholine levels (R). A decrease in hippocampal acetylcholinesterase activity increases anxiety- and depression-like behaviors and decreases resilience to repeated stress during social defeat (R).
• (In excess) Enhances aggression (R).
• Increases CB1 receptors, which are involved in fatigue and getting the munchies (R).
• Increases the signal-to-noise ratio in a learning environment, which can help with focus and reduce being distracted. But too much can cause someone to become too fixated on something and reduces cognitive flexibility, whereas too little could contribute to ADHD.
• Is involved in fear learning, so too much can make some people too afraid to retry something or even try something new that’s closely related to a certain fear. When acetylcholine input to the amygdala (the part of the brain that’s involved in emotion) is high at baseline, behavioral responses to negative stimuli are likely to be maximal and negative events may be more efficiently stored as negative memories.
• Inhibits tonic (baseline) dopamine, but promotes phasic bursts. Meaning, you’ll have lower overall brain dopamine, but get larger bursts of dopamine when doing something fun/exciting. This contributes to addiction. Nicotinic receptor α3, α6 and β3 subunits are enriched in midbrain nuclei associated with behavioral reinforcement. Blocking mAChRs have anti-addictive properties.
• Contributes to rumination (reduces mental flexibility), with a bias towards negative memories.
• Improves attention and by extension, learning and memory; however, in the absence of cholinergic neuronal loss, stimulation of acetylcholine signaling can impair memory (R).
• Promotes REM sleep and vivid dreams. Lucid dream promoting supplements usually contain one or more cholinergic. An excess can also promote excessive dreaming and contribute to insomnia.
• Causes illusory sensations.
• Contributes to dysphoria, which is a state of unease or generalized dissatisfaction with life.
• Contributes to irritability and hostility.
• Can cause delirium, confusion, headache, or drowsiness.
• Is involved in OCD. Cholinergic supersensitivity is present in obsessive-compulsive disorder (R). Similarly, glutamatergic hyperactivity is associated with OCD, which may be because nicotinic receptor activation releases glutamate (R).

Excess acetylcholine in the body:​

• Decreases heart rate. Usually, people that are very fit or do keto have reduced heart rate and this is due to excess acetylcholine activity. Eating carbs, which increases the release of insulin, normalizes heart rate again. Too much acetylcholine can cause paralysis of the heart which stops it from beating.
• Increases body temperature and is involved with flushing and excessive sweating.
• Increases blood pressure due to increasing aldosterone and vasopressin. Although in smaller amounts it can contribute to vasodilation by releasing nitric oxide, possibly by increasing the aromatase (R).
• Could contribute to cold hands and feet, since it increases adrenaline secretion through nicotinic receptor activation.
• Contributes to pancreatitis (R).
• Causes cramps.
• Promotes mucus/liquid secretion from the mouth (excess saliva), nose, throat, eyes (lacrimation), skin (sweating) and infected/inflamed areas.
• Contributes to constriction/contraction of the throat, which is involved in asthma / COPD / sleep apnea (R, R).
• Releases too much gastric acid and can contribute to stomach ulcers.
• Contracts the bladder, giving the sensation of “small bladder syndrome” and increases the urge to urinate. Too little acetylcholine can lead to urine buildup and reduced the urge to urinate, which can actually contribute to bladder inflammation.
• Contracts the smooth muscle in the gastrointestinal tract and can lead to diarrhea if in excess. Too little can contribute to constipation.
• Contributes to muscular fasciculation (twitching) (is also involved in the dopamine induced dyskinesias (R)), muscular weakness, paralysis and the disease called Myasthenia gravis (through nicotinic receptor activation).
• Constricts pupils and can contribute to blurry vision. If you ever wondered why some people have such very small pupils, it’s because of elevated acetylcholine and serotonin. As a side note, acetylcholine eye drops can be used for glaucoma.
• Reduces thirst. Inhibiting acetylcholine can cause loss of parasympathetic activity (and increase thirst and cause constipation). This is why insulin can make people thirsty, because insulin opposes acetylcholine.
• Increases cortisol. The nAChR antagonist, mecamylamine, has been found to block the physostigmine (a highly toxic parasympathomimetic alkaloid)-induced rise in plasma corticosterone levels in rats. In addition, acetylcholine-induced CRH release from the hypothalamus is inhibited by nAChR blockade (R).
• Stimulates prolactin release (R).
• Can make you feel nauseous and cause vomiting through the mAChR activation.
• Contribute to epileptic episodes.

Now that you got a pretty good idea what high/low acetylcholine looks like, let’s discuss what can lower excess acetylcholine and provide relief from these symptoms.

Anticholinergics:

• Procaine
• Quinidine
• Magnesium ( it antagonizes P-type calcium channels)
• Atropine
• Jimson weed
• Adamantane/amantadine/memantine
• Quinine in tonic water
• Compounds found in foods part of the deadly nightshade (Atropa belladonna) such as tomatoes, potatoes, and eggplant
• Hyoscyamine (which has 98% of the anticholinergic power of atropine) found in Solanaceae, including henbane, mandrake, angel’s trumpets, jimsonweed, tomato and the sorcerers’ tree. It can also be anti-serotoninergic.
• Hyoscine found in the corkwood tree, which has been previously used to treat nausea and seasickness amongst other things.
• Progesterone inhibits rat neuronal nAChRs (R).
• Dehydroepiandrosterone sulfate (DHEA-S) inhibits rat neuronal nAChRs (R). DHEA-S also activates the sigma receptor which promotes the release of dopamine and acetylcholine. So it can lead to more acetylcholine and less nAChRs activation, which could be how it contributes to depersonalization/anhedonia.
• Hydrocortisone inhibit rat neuronal nAChRs (R)
• 3α,5α,17β-3-hydroxyandrostane-17-carbonitrile (ACN) inhibit rat neuronal nAChRs (R).
• Pregnenolone-sulfate inhibits nAChR-regulated release of catecholamines from the adrenal medulla (R).
• T3 inhibits nAChR (R).
• Lower doses (2.5–5 mg b.i.d.), mecamylamine (anti-hypertensive drug) functions as a potent centrally acting nAChR antagonist that may be useful for treating tobacco, cocaine and alcohol dependency (R).
• Bupropion (Zyban®) is relatively selective at inhibiting α3β2-nAChRs.
• Organic mercurial compounds, such as methylmercury, can cause dysfunction of the enzyme choline acetyltransferase. This inhibition may lead to acetylcholine deficiency and can have consequences on motor function.
• Botulinum toxin (Botox) suppresses the release of acetylcholine.
• Cysteine inhibits choline acetyltransferase (R).
• Angiotensin inhibits acetylcholine release and can lead to cognitive defects (R).
• Dopamine receptor D2 agonist (R)
• Hyperventilation (low CO2) lowers acetylcholine, whereas high CO2 and ATP increases the release of acetylcholine (R, R).
• Vitamin A and K decreased the synthesis of acetylcholine in low and increasing concentrations (R).
• Vitamin D only decreases acetylcholine synthesis in higher doses(R).
• Vitamin B1 slightly increases the synthesis of acetylcholine in low concentrations and decreases it in higher ones (R).
• Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate (a pesticide that inhibits acetylcholinesterase) exposure (R).
• Chinese Peony (R)

Pro-acetylcholine

• Huperzine increases both acetylcholine & dopamine and can protect against Alzheimers by decreasing iron content in the brain (R).
• Betaine, folate and B12 can spare choline, through the methylation cycle.
• Jaborandi
• CRP and other markers of systemic inflammation decrease the expression of AChE, resulting in a reduced breakdown of acetylcholine.
• Loss of cholinergic neurons can lead to low acetylcholine release. Anti-oxidant enzymes containing, zinc, copper, iron, manganese and selenium can help protect cholinergic neurons against oxidative stress. Other neuroprotective factors include progesterone, pregnenolone, taurine, agmatine, methylene blue, magnesium, etc.
• Vitamin B5is essential for the production of acetyl-CoA, which can then be used to create acetylcholine (R).
• The active form of vitamin D, 1,25-(OH)2D3, increases acetylcholine synthesis. A low calcium diet can lead to an excess of acetylcholine, by increasing the amount of active vitamin D (R).
• A vitamin B1 deficiency results in reduced activity of choline acetyltransferase (ChAT), in the cortex and hippocampus and can lead to memory impairment (R). In this study, 200mg intravenous significantly reduced symptoms of delirium (R). Benfotiamine appears to improve the cognitive function and reduce amyloid deposition via thiamine-independent mechanisms, which are likely by suppressing glycogen synthase kinase-3 (GSK-3) activities (R). Combining citicoline combined with benfotiamine offers greater benefits for memory impairment in mice than either one alone (R).
• Pesticides (organophosphates and the carbamates) inhibit acetylcholinesterase, which is implicated in depression.
• Estrogen (R)
• Dopamine D1 receptor agonist (R).
• Activation of the serotonin receptor, 5-HT2A boosts the release of acetylcholine after stimulation of dopamine D1 receptors (R). Serotonin, by binding to the 5-HT1A receptor can also activate the parasympathetic nervous system via the release of acetylcholine (R).
• The venom from a black widow spider (alpha-latrotoxin) stimulates acetylcholine release. When bitten by a black widow spider, one experiences the wastage of acetylcholine supplies and the muscles begin to contract. If and when the supply is depleted, paralysis occurs.
• Muscarine, a poisonous molecule found in mushrooms (Amanita muscaria), induces a strong activation of the peripheral parasympathetic nervous system (muscarinic syndrome) (R).
• Carpolobia lutea (cholinesterase inhibitor) (R)
• Catuaba bark (R).
• Activation of the sigma receptor releases acetylcholine. Progesterone and testosterone are antagonistic and can lower excess acetylcholine release, whereas choline, DHEA-S and pregnenolone-S are agonistic (R, R).
• Morphine, by acting on the kappa opioid receptor (R).
• Galantamine inhibits acetylcholinesterase and also acting as a positive allosteric modulator of α7 nAChR.
• Memantine increases acetylcholine in the nucleus accumbens & ventral tegmental area (R).
• Bitters, such as coffee, gentian, etc. (R).
• Sage (R)
• Saffron (30mg) (R)
• Vitamin B2, B3 (niacin and nicotinamide), B5, B6, and vitamin C increase acetylcholine synthesis in high doses (R).
• Vitamin E increases the synthesis of acetylcholine (R).

 

[excelnelg]

For anyone looking at this as inspiration, please consider that a 79 year old brain is VASTLY different from a 39 or 49 year old brain.

 

[NitricOxideNutritionDoc]

Just a warning that choline can cause or worsen depression in some susceptible individuals (like myself). There is a cholinergic theory of depression that was dominant for awhile, which posited that an imbalance of neurotransmitters, favoring acetylcholine, is a primary cause of depression. This was supported by the fact that certain anticholinergic medications were known to boost mood or cause euphoria, while acetylcholinesterase inhibitors often cause depression. Obviously, we know now that this is not the whole story of depression, but acetylcholine remains an important and usually unhelpful factor in mood disorders.

Cholinergic Regulation of Mood: From Basic and Clinical Studies to Emerging Therapeutics - PMC

Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems ...

www.ncbi.nlm.nih.gov

Also, choline can be converted into a potentially very dangerous metabolite called TMAO. Garlic extracts containing high levels of allicin may be able to help mitigate the conversion of choline (and carnitine) into TMAO.

 

[SkiDaddy]

If choline is the precursor to phosphatidylcholine, why not take phosphatidylcholine?

 

[Vince]

If choline is the precursor to phosphatidylcholine, why not take phosphatidylcholine?

Phosphatidylcholine (PC) supplements may have some side effects, including:

• Muscle weakness and seizures
  When combined with cholinesterase inhibitors, PC can increase acetylcholine levels, which can lead to muscle weakness and seizures. PC supplements should not be taken with AChE inhibitors unless under a doctor's care.
• Cellular viability
  Prolonged use of choline from PC for acetylcholine production may lead to a loss of phosphatide, impaired membrane function, and loss of cellular viability.
• Cardiovascular disease
  Studies have linked higher dietary intakes of PC to a higher risk of cardiovascular disease-related mortality.
• Fatty tumors
  PC injections may cause non-cancerous fatty tumors to become fibrous, which may require surgical removal.
• Stomach upset and diarrhea
  When taken orally, PC can sometimes cause stomach upset and diarrhea.

Office of Dietary Supplements - Choline

Choline overview for health professionals. Research health effects, dosing, sources, deficiency symptoms, side effects, and interactions here.

ods.od.nih.gov

 

[Vince]

Choline associated hypersexuality in a 79-year-old man​

I don't believe this is true..... Just my 2¢