Case Study: Priapism Caused by Synthetic Cannabinoids?

Synthetic cannabinoids are designer drugs that differ in some significant ways from the natural cannabinoids found in cannabis plants. They are often marketed as designer drugs or sold in products with claims they give the same effect as cannabis.

Synthetic cannabinoids (SCs) have been increasingly used all over the world, particularly among young?adult population. SCs can cause severe adverse effects on several organ systems. However, there are no studies in the literature which have stated the possible relationship between using of SCs and priapism. We present a case of 28?year?old man who was diagnosed with a 58?hr lasting priapism after regular administrations of SCs.

  • The priapism did not resolve either after applying aspiration with irrigation or shunt surgery.

  • Penile prosthesis implantation was performed as a last treatment option.

  • The SCs have been increasingly used among young population in recent years; therefore, new SC?related ischaemic priapism cases might be encountered in the emergency departments


"A new cause of ischaemic priapism: Synthetic cannabinoids," [style=font-style: italic;]Andrologica,[/style]1 April 2018, https://onlinelibrary.wiley.com/doi/full/10.1111/and.13013
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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