Canadian With Questions on Daily Injections

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bluerage

Member
I inject 42mg E3D and am curious about ED injections. Just a few questions:
1. Since I draw blood on trough day (gives me lowest totals of the week) Wouldn't an ED injection numbers alarm my doc? I'm assuming the numbers would be somewhere between the peak and trough which would be (significantly?)_ higher than what he/she use to seeing?
2. How would an ED protocol effect FT and bioavailable T? My TT levels are in the upper middle range but my Ft is in the upper range, while my bioavailable is over the range. I'm not sure which of the 3 measurements is most important for TRT.
3. Since an ED protocol seems to lower aromatization would this mean more of the T would convert to DHT? Being from Canada I don't have easy access to the sensitive assay so I have no idea of my Estradiol levels but I do know that my DHT is higher than I'd like. Numbers show that it's at the very top of the range and I've notice significant hair loss since starting as well as acne.
I hope that these aren't silly questions.
 
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CoastWatcher

Moderator
I inject 42mg E3D and am curious about ED injections. Just a few questions:
1. Since I draw blood on trough day (gives me lowest totals of the week) Wouldn't an ED injection numbers alarm my doc? I'm assuming the numbers would be somewhere between the peak and trough which would be (significantly?)_ higher than what he/she use to seeing?
2. How would an ED protocol effect FT and bioavailable T? My TT levels are in the upper middle range but my Ft is in the upper range, while my bioavailable is over the range. I'm not sure which of the 3 measurements is most important for TRT.
3. Since an ED protocol seems to lower aromatization would this mean more of the T would convert to DHT? Being from Canada I don't have easy access to the sensitive assay so I have no idea of my Estradiol levels but I do know that my DHT is higher than I'd like. Numbers show that it's at the very top of the range and I've notice significant hair loss since starting as well as acne.
I hope that these aren't silly questions.

I'm a Canadian who has injected for the past 22 months. In my doctor's practice there are a solid minority of us who follow such a protocol. So, discuss it with your doctor - it's a valid approach to managing hypogonadal patients, particularly ones with lower SHBG, estradiol issues, and those who for whatever reason want to maintain steady-state levels.

Why are you considering a move to daily shots? How do you feel on your current protocol?

In regard to your questions, what sort of values are you posting currently? If you and your doctor adopt a daily protocol, there should be no reason your next set of labs should alarm anyone - just the opposite.

Canadian labs have some of the lowest ranges for total, free, and bio-available testosterone in the western world. Two years ago they were lowered. Many doctors are convinced they reflect societal concerns about TRT and not medical realities. In my doctor's practice, she relies on the standards used at one of the local hospitals and LabCorp, the US lab, to guide her.

Finally, I regularly rest my e2 in the States. If that's not an option for you, and it may well not be, you've managed to navigate the challenges of estradiol so far. In most of us, though not all, e2 is not an issue as peaks are avoided. My DHT, hasn't really budged from around 60% of the reference range.

Post up your numbers and we can dig a bit deeper.
 

bluerage

Member
Thanks Vince. I assume the troughs will be shallower than if the injections were spread further apart?
I did have my SHBG checked once before starting and once after. I'll have a look for the numbers as well as posting my most recent bloodwork.
 

bluerage

Member
Pre TRT numbers in 2014
TT 9.7 5.5-25.2 nmol/L
BioAvailable T 5.81 3.3-14.1 nmol/L
SHBG 14 10-57 nmol/L
Albumin 41 35-50g/L
DHT 2930 860-3406 pmol/L

April 2017 42mg E3D shallow IM
TT 21 8.4-28.8 nmol/L
Free T 629 196-636 pmol/L
BioAvailable 14.7 3.6-11.2 nmol/L

I wanted to test my DHT as it has been high in the past but as the doctor said what difference would the results make? I likely wouldn't lower my dose based on my T numbers and I won't take anything that blocks DHT conversion as I've read that these drugs have negative impact on erectile function.
My interest in daily injections is in hopes of raising my TT without raising DHT (hair loss) while reducing estradiol (acne). Is there any reason to believe that daily injections would help with erections?
 

CoastWatcher

Moderator
Pre TRT numbers in 2014
TT 9.7 5.5-25.2 nmol/L
BioAvailable T 5.81 3.3-14.1 nmol/L
SHBG 14 10-57 nmol/L
Albumin 41 35-50g/L
DHT 2930 860-3406 pmol/L

April 2017 42mg E3D shallow IM
TT 21 8.4-28.8 nmol/L
Free T 629 196-636 pmol/L
BioAvailable 14.7 3.6-11.2 nmol/L

I wanted to test my DHT as it has been high in the past but as the doctor said what difference would the results make? I likely wouldn't lower my dose based on my T numbers and I won't take anything that blocks DHT conversion as I've read that these drugs have negative impact on erectile function.
My interest in daily injections is in hopes of raising my TT without raising DHT (hair loss) while reducing estradiol (acne). Is there any reason to believe that daily injections would help with erections?

Like so many aspects of TRT, the answer to your question - if daily injections would help with erections - is...it might. I'm not being snide. In my own case, daily injections (and as close to true steady-state as I'm likely to achieve) allowed me to abandon citrulline and argenine supplements. I do continue to take Cialis, 5mg, on a daily basis. My erection quality is excellent. Not everyone has that experience. Have you seen an improvement in erections as your numbers have improved?
 

bluerage

Member
To a certain extent. The biggest difference I've noticed has been libido improving. I use to have trouble maintaining an erection during intercourse but for the most part that's been resolved. Erection quality however still remains a problem. Cialis helps but unfortunately my insurance will not cover it.
Was there a reason you highlighted the DHT range?
 

CoastWatcher

Moderator
To a certain extent. The biggest difference I've noticed has been libido improving. I use to have trouble maintaining an erection during intercourse but for the most part that's been resolved. Erection quality however still remains a problem. Cialis helps but unfortunately my insurance will not cover it.
Was there a reason you highlighted the DHT range?
That's some sort of system quirk.
 
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