Can Methylene Blue cause erectile dysfunction?

[champion]

I have been doing some research on Methylene Blue and it seems that it blocks the release of nitric oxide. Since nitric oxide is necessary for an erection could Methylene Blue cause erectile dysfunction?

 

[t_spacemonkey]

i never experienced this even at 100mg doses

 

[champion]

i never experienced this even at 100mg doses

Could you explain what benefits you got from it?

 

[t_spacemonkey]

Could you explain what benefits you got from it?

i definitely got a mood boost. i noticed that i woke up feeling more rested/happier. but pretty inconsistent however. this has probably to do with the serotonin boost it gives you. i took it for 3 months or so at 15mg/day while frequently going to 50-100mg. i stopped eventually because I did not feel that a) the mood boost held up more then couple times b) no other benefits noted

 

[champion]

i definitely got a mood boost. i noticed that i woke up feeling more rested/happier. but pretty inconsistent however. this has probably to do with the serotonin boost it gives you. i took it for 3 months or so at 15mg/day while frequently going to 50-100mg. i stopped eventually because I did not feel that a) the mood boost held up more then couple times b) no other benefits noted

Thanks, I appreciate you taking the time to reply.

 

[Guided_by_Voices]

Several things...1)The big-brains on MB (e.g. Fransisco Gonzalez-Lima) seem to suggest that for general benefit, intermittent low-dose use is the way to go. For example, I use less than 5 mg one or two times per week. 2) Nitric Oxide is a very complicated topic in itself and from what I understood of the podcasts I've heard from people who study it, it is another case where too much can be bad as well as too little. 3) My take away from a quick scan of the topic is that it's very unclear if it is even reducing NO in a meaningful way, let alone one that would affect erections 4) Other aspects of MB should have a positive affect on the endothelium in general and hence NO, such as enhanced cardio performance, and 5) MB seems to have so many net-benefits that the risk/reward seems firmly tilted toward reward, at least when used intermittently in low doses, similar to how rapamycin (and many other things like insulin) seem beneficial when used that way but likely harmful to an otherwise healthy person when used chronically in high doses.

Here's an example in the linked podcast of the complexity of the NO topic...

‎Super Human Radio: SHR # 2202 :: B6 Metabolism, Nitric Oxide, Stress Signaling, Cancer and Neural Pathologies :: on Apple Podcasts

‎Show Super Human Radio, Ep SHR # 2202 :: B6 Metabolism, Nitric Oxide, Stress Signaling, Cancer and Neural Pathologies :: - Jun 10, 2018

podcasts.apple.com