Can Marijuana Increase Estradiol and Contribute to Man Boobs (Gynecomastia)?

Animal studies have shown that exposure to the active ingredient in marijuana can result in a decrease in testosterone levels, a reduction of testicular size, and abnormalities in the form and function of sperm.

In humans, the effects of marijuana on testosterone and estrogen levels aren't as clear. Lower testosterone levels have been reported in chronic marijuana users compared to nonusers, but not all studies support this.

Few studies have examined a direct causative effect between smoking marijuana and gynecomastia. A report in 1972 made the initial connection between cannabis and gynecomastia. This study is contrasted with a 1977 survey of U.S. Army soldiers which showed no association between smoking marijuana and gynecomastia. This study was limited, however, due to its very small sample size.

http://www.cnn.com/2013/12/05/health/youn-pot-moobs/
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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