Can adding Clomid to a TRT regimen raise estradiol?

JamesAxe

New Member
Hi guys, read these boards all the time and would love to get some feedback on my question.

I have been through many trt regimens throughout the years, and one of my recent changes from a new doctor was to take 40mg of test cyp e3d. After 8 weeks on this, it put my total T at 690, free T at 14.5, and e2 at 22 for my tests. DHT, DHEA, everything came back perfect dead center of range. SHBG is 35.

He told me to add 25mg clomid e3d as well to my regimen to keep the testicles working (yes I know this doesn't really work, but I tried it anyway).

After 6 weeks of added Clomid, everything stayed the same, but my e2 went up to 32. My e1 also decreased slightly.

Question: Since clomid is blocking certain e2 receptors, and tricking the brain, into thinking there is less, is it possible that the clomid was what was responsible for the increase in e2? Or is my e2 just creeping up over time (I figured at these numbers it shouldnt as I usually dont aromatize easily).

Thanks guys.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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