Can a pill increase Testosterone?


What if there was a pill that could increase testosterone without injections or topical applications? In this episode, Dr. Geo Espinosa sits down with Shalin Shah, a leader in metabolic health and CEO of Verity Pharma, to discuss oral testosterone therapy and the FDA-approved drug Kyzatrex.




* Does this new pill actually work?

* How does it affect SHBG & free testosterone?

* What are the side effects compared to injections & gels?

* Can it help prevent muscle loss with GLP-1 agonists like Ozempic?




This eye-opening discussion dives into the science, benefits, and future of testosterone therapy, tackling common concerns and misconceptions around hormonal health in men.
Chapters



Chapters


00:00 A Pill to Increase Testosterone with Shalin Shah
01:28 Why Oral Testosterone Has Failed in the Past
02:28 How Kyzatrex Works & What Makes It Different
04:24 Shalin Shah’s Background & Role in Testosterone Innovation
05:16 The Evolution of Testosterone Replacement Therapy (TRT)
08:29 Addressing Concerns: SHBG, Free Testosterone & Side Effects
11:29 Testosterone & Cardiovascular Health – FDA Hurdles Explained
26:47 History of Testosterone & How It’s Used Today
27:31 The Science Behind SHBG & Its Impact on Testosterone
28:55 How to Optimize Testosterone Levels Naturally & Medically
37:56 GLP-1 Agonists (Ozempic, Mounjaro) & Muscle Preservation
39:18 Combining Therapies: GLP-1 & TRT for Metabolic Health
45:14 Strength Training & Hormonal Balance – Why It Matters
47:47 Final Thoughts: Future of Testosterone Therapy & What’s Next
50:24 Closing Remarks – How to Stay Informed
 
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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