Calling experts! Fatty liver and estrogen dominance requires some (evil) Ai's

Fernando Almaguer

Well-Known Member
Hi TRT teammates,

In fatty liver disease, one of the inabilities created is lowered ability to metabolize estrogen in the liver. If on trt e2 can have a tendency to rise. If one is on TRT and e2 can rise significantly due to low metabolism in the liver. Would it be safe to say, in your opinion to take some sort of aromatase inhibitor to help with the build up in estradiol?
 
I would first try to dial in dose, injection frequency, if you STILL have high e2 symptoms then you can try 60-90mg zinc citrate, if even then still high e2 symptoms persist then you can try some micro doses of AI. Cannot give any guidance on dosing AI, never used any
 
I would first try to dial in dose, injection frequency, if you STILL have high e2 symptoms then you can try 60-90mg zinc citrate, if even then still high e2 symptoms persist then you can try some micro doses of AI. Cannot give any guidance on dosing AI, never used any
How effective is the zinc, have you tried it?
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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