Bipolar Androgen Therapy a new endocrinologic treatment for CRPC

madman

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The video presented a treatment called Bipolar Androgen Therapy (BAT) for prostate cancer, in which patients are given high doses of testosterone to resensitize the cancer to hormone therapy. Dr. Sam Denme discussed the concept, results from trials, and future research, highlighting the potential of BAT to improve survival, and quality of life, and resensitize cancer to hormone treatments. The talk also addressed the challenges and potential risks associated with BAT, as well as the need for further studies and funding to explore different methods and combinations for more effective treatment. Overall, BAT offers hope for prostate cancer patients who have become resistant to traditional hormone therapy.

Key Takeaways:
  • Dr. Sam Denme discussed Bipolar Androgen Therapy (BAT) and its potential benefits for prostate cancer treatment.
  • BAT involves administering high doses of testosterone to resensitize cancer to hormone therapy.
  • BAT may improve survival, and quality of life, and resensitize cancer to hormone treatments. Offers hope for patients resistant to traditional hormone therapy.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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