Best Way to Increase Semen ?
- Thread starter steve14
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CoastWatcher
Moderator
You are on TRT? Reduced ejaculate is a typical consequence of androgen therapy. Might you be dealing with retrograde ejaculation? Are you taking medication for BPH?
no im 100% in good health condition. im not on TRT , no retrograde ejaculation or medication for BPH .
i just want to know which medications and supplements increase the semen amount . thats all
thank you for your answer.
Vince Carter
Banned
Pygeum is one that is supposed to increase ejaculate, or Sunflower Lecithin, is another. Didn't do anything for me.
Nelson Vergel
Founder, ExcelMale.com
Pygeum helped some for me, mostly preejaculate.
Nelson Vergel
Founder, ExcelMale.com
Andrologia. 2018 Oct;50(8):e13071. doi: 10.1111/and.13071. Epub 2018 Jul 10.
Effects of a micronutrient supplementation combined with a phosphodiesterase type 5 inhibitor on sperm quantitative and qualitative parameters, percentage of mature spermatozoa and sperm capacity to undergo hyperactivation: A randomised controlled trial.
Tsounapi P1, Honda M1, Dimitriadis F2, Koukos S3, Hikita K1, Zachariou A3, Sofikitis N3, Takenaka A1.
Abstract
The main objective of this study was to evaluate the effects of a micronutrient supplementation (MS) combined with avanafil on sperm function. Oligoasthenospermic men (n = 217) were treated daily for 90 days with either an MS (45 men, Group A), l-carnitine (44 men, Group B), MS plus avanafil (43 men, Group C) or avanafil (43 men, Group D); another group of 42 men with oligoasthenospermia (Group E) received no treatment. Sperm parameters were evaluated before and after the end of treatment in each Group A, B, C and D respectively. The same sperm parameters were measured in each participant of Group E before and at the 90-day experimental period. Within Groups A, C or D, the total percentage of motile spermatozoa, the hypoosmotic swelling test (HOST) result and the percentage of hyperactivated spermatozoa after incubation under conditions known to induce sperm capacitation were significantly greater after MS or MS plus avanafil treatment, or avanafil treatment than before the respective treatment. We suggest that MS or MS plus avanafil combined administration or avanafil alone improves sperm membrane permeability with an overall result improvement in sperm motility, outcome of HOST and increase in the percentage of hyperactivated spermatozoa.
Effects of a micronutrient supplementation combined with a phosphodiesterase type 5 inhibitor on sperm quantitative and qualitative parameters, percentage of mature spermatozoa and sperm capacity to undergo hyperactivation: A randomised controlled trial.
Tsounapi P1, Honda M1, Dimitriadis F2, Koukos S3, Hikita K1, Zachariou A3, Sofikitis N3, Takenaka A1.
Abstract
The main objective of this study was to evaluate the effects of a micronutrient supplementation (MS) combined with avanafil on sperm function. Oligoasthenospermic men (n = 217) were treated daily for 90 days with either an MS (45 men, Group A), l-carnitine (44 men, Group B), MS plus avanafil (43 men, Group C) or avanafil (43 men, Group D); another group of 42 men with oligoasthenospermia (Group E) received no treatment. Sperm parameters were evaluated before and after the end of treatment in each Group A, B, C and D respectively. The same sperm parameters were measured in each participant of Group E before and at the 90-day experimental period. Within Groups A, C or D, the total percentage of motile spermatozoa, the hypoosmotic swelling test (HOST) result and the percentage of hyperactivated spermatozoa after incubation under conditions known to induce sperm capacitation were significantly greater after MS or MS plus avanafil treatment, or avanafil treatment than before the respective treatment. We suggest that MS or MS plus avanafil combined administration or avanafil alone improves sperm membrane permeability with an overall result improvement in sperm motility, outcome of HOST and increase in the percentage of hyperactivated spermatozoa.
Nelson Vergel
Founder, ExcelMale.com
Eur Urol. 2019 Jan 7. pii: S0302-2838(18)31027-3. doi: 10.1016/j.eururo.2018.12.022. [Epub ahead of print]
Benefits of Empiric Nutritional and Medical Therapy for Semen Parameters and Pregnancy and Live Birth Rates in Couples with Idiopathic Infertility: A Systematic Review and Meta-analysis.
Omar MI1, Pal RP2, Kelly BD3, Bruins HM4, Yuan Y5, Diemer T6, Krausz C7, Tournaye H8, Kopa Z9, Jungwirth A10, Minhas S11.
Abstract
CONTEXT:
Empiric use of medical and nutritional supplements to improve semen parameters and pregnancy rates in couples with idiopathic infertility has reached global proportions, although the evidence base for their use in this setting is controversial.
OBJECTIVE:
We systematically reviewed evidence comparing the benefits of nutritional and medical therapy on pregnancy rates and semen parameters in men with idiopathic infertility.
EVIDENCE ACQUISITION:
A literature search was performed using MEDLINE, Embase, LILACS, and the Cochrane Library (searched from January 1, 1990 to September 19, 2017). using the methods detailed in the Cochrane Handbook. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess the certainty of evidence.
EVIDENCE SYNTHESIS:
The literature search identified 5663 citations, and after screening of abstracts and full texts, 61 studies (59 randomised controlled trials and two nonrandomised comparative studies) were included. Pooled results demonstrated that pentoxyfylline, coenzyme Q10, L-carnitine, follicle-stimulating hormone, tamoxifen, and kallikrein all resulted in improvements in semen parameters. Individual studies identified several other medical and nutritional therapies that improved semen parameters, but data were limited to individual studies with inherent methodological flaws. There were limited data available on live birth and pregnancy rates for all interventions. The GRADE certainty of evidence for all outcomes was very low mainly owing to methodological flaws and inconsistencies in study design. Some outcomes were also downgraded owing to imprecision of results.
CONCLUSIONS:
There is some evidence that empiric medical and nutritional supplements may improve semen parameters. There is very limited evidence that empiric therapy leads to better live birth rates, spontaneous pregnancy, or pregnancy following assisted-reproductive techniques. However, the findings should be interpreted with caution as there were some methodological flaws, as a number of studies were judged to be either at high or unclear risk of bias for many domains.
PATIENT SUMMARY:
This review identified several medical and nutritional treatments, such as pentoxyfylline, coenzyme Q10, L-carnitine, follicle-stimulating hormone, tamoxifen, and kallikrein, that appear to improve semen parameters. However, there are limited data suggesting improvements in pregnancy and live birth rates. The lack of evidence can be attributed to methodological flaws in studies and the low number of pregnancies reported.
Benefits of Empiric Nutritional and Medical Therapy for Semen Parameters and Pregnancy and Live Birth Rates in Couples with Idiopathic Infertility: A Systematic Review and Meta-analysis.
Omar MI1, Pal RP2, Kelly BD3, Bruins HM4, Yuan Y5, Diemer T6, Krausz C7, Tournaye H8, Kopa Z9, Jungwirth A10, Minhas S11.
Abstract
CONTEXT:
Empiric use of medical and nutritional supplements to improve semen parameters and pregnancy rates in couples with idiopathic infertility has reached global proportions, although the evidence base for their use in this setting is controversial.
OBJECTIVE:
We systematically reviewed evidence comparing the benefits of nutritional and medical therapy on pregnancy rates and semen parameters in men with idiopathic infertility.
EVIDENCE ACQUISITION:
A literature search was performed using MEDLINE, Embase, LILACS, and the Cochrane Library (searched from January 1, 1990 to September 19, 2017). using the methods detailed in the Cochrane Handbook. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess the certainty of evidence.
EVIDENCE SYNTHESIS:
The literature search identified 5663 citations, and after screening of abstracts and full texts, 61 studies (59 randomised controlled trials and two nonrandomised comparative studies) were included. Pooled results demonstrated that pentoxyfylline, coenzyme Q10, L-carnitine, follicle-stimulating hormone, tamoxifen, and kallikrein all resulted in improvements in semen parameters. Individual studies identified several other medical and nutritional therapies that improved semen parameters, but data were limited to individual studies with inherent methodological flaws. There were limited data available on live birth and pregnancy rates for all interventions. The GRADE certainty of evidence for all outcomes was very low mainly owing to methodological flaws and inconsistencies in study design. Some outcomes were also downgraded owing to imprecision of results.
CONCLUSIONS:
There is some evidence that empiric medical and nutritional supplements may improve semen parameters. There is very limited evidence that empiric therapy leads to better live birth rates, spontaneous pregnancy, or pregnancy following assisted-reproductive techniques. However, the findings should be interpreted with caution as there were some methodological flaws, as a number of studies were judged to be either at high or unclear risk of bias for many domains.
PATIENT SUMMARY:
This review identified several medical and nutritional treatments, such as pentoxyfylline, coenzyme Q10, L-carnitine, follicle-stimulating hormone, tamoxifen, and kallikrein, that appear to improve semen parameters. However, there are limited data suggesting improvements in pregnancy and live birth rates. The lack of evidence can be attributed to methodological flaws in studies and the low number of pregnancies reported.
Buffbanker
New Member
Pygeum has worked well for me in addition to black maca and letchitin. Although I came across numerous studies on PubMed stating that two active ingredients are androgen receptor antagonists. Specifically, the compounds are able to displace a statistically significant amount of Testosterone and DHT at the AR receptor site. Therefore counteracting some of the benefits of TRT. Now I am a bit hesitant to use this again. In other in vitro studies it was found to also displace bound estrogen at the ER receptor. I had an abnormal sensitive E2 lab test at 277 pg/mL while taking Pygeum. I had a retest done since I suspected a lab error a week later and got a result of 58 pg/mL. So it’s possible that itbskewed the result. I have a follow lab Monday now that it has been a few weeks and should be completely out of my system to determine if Pygeum has more AR and ER agonist activity than we should be comfortable with while on TRT.
The natural compounds atraric acid and N-butylbenzene-sulfonamide as antagonists of the human androgen receptor and inhibitors of prostate cancer c... - PubMed - NCBI
NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth. - PubMed - NCBI
The natural compounds atraric acid and N-butylbenzene-sulfonamide as antagonists of the human androgen receptor and inhibitors of prostate cancer c... - PubMed - NCBI
NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth. - PubMed - NCBI
Nelson Vergel
Founder, ExcelMale.com
Can you INCREASE your semen VOLUME? Shooters vs. Dribblers?
"How can I increase my semen volume!?" is one of the most common questions I get from my patients. More importantly, does having MORE semen volume account for better sex? What are the ways to increase semen volume? Find out at the end of the video!
www.excelmale.com
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