madman
Super Moderator
Conclusions
Previous research provided evidence that testosterone treatment is effective in reducing depressive symptoms in hypogonadal or middle-aged men up to age 60 years.This meta-analysis provides important new evidence that testosterone treatment may also be effective and efficacious for eugonadal and older men when higher testosterone dosages are administered. For acceptability, testosterone treatment was not significantly associated with fewer dropouts than placebo. Safety monitoring in testosterone treatment trials continues to be important owing to a lack of sufficiently powered longterm studies to determine increased risk for adverse events. Because our results as well as previous investigations have indicated that risk of bias is considerable in most studies, we call for large, preregistered RCTs of good quality investigating testosterone treatment’s effect inmen on depression as the primary outcome.
Previous research provided evidence that testosterone treatment is effective in reducing depressive symptoms in hypogonadal or middle-aged men up to age 60 years.This meta-analysis provides important new evidence that testosterone treatment may also be effective and efficacious for eugonadal and older men when higher testosterone dosages are administered. For acceptability, testosterone treatment was not significantly associated with fewer dropouts than placebo. Safety monitoring in testosterone treatment trials continues to be important owing to a lack of sufficiently powered longterm studies to determine increased risk for adverse events. Because our results as well as previous investigations have indicated that risk of bias is considerable in most studies, we call for large, preregistered RCTs of good quality investigating testosterone treatment’s effect inmen on depression as the primary outcome.
