Aquablation: Powerful Relief for Big Prostate LUTS in BPH

madman

Super Moderator
Aquablation, a treatment for benign prostatic hyperplasia, has demonstrated positive outcomes with low morbidity in large prostates (>80 mL). A study found significant and sustained improvements in patient symptoms, including a decrease in International Prostate Symptom Score and an increase in maximum urinary flow rate. Aquablation showed reproducible clinical outcomes and a low re-treatment rate at 5 years. While the study lacked a comparison group, previous trials showed similar results. Aquablation offers a viable option for men seeking to preserve continence, erectile function, and ejaculatory function.




Key Points:
  • The study reports 5-year safety and efficacy outcomes of the Aquablation procedure for treating symptomatic benign prostatic hyperplasia with large-volume prostate glands
  • 101 men with moderate to severe symptoms and prostate volumes between 80 and 150 mL underwent robotic-assisted Aquablation in a multicenter trial
  • The study successfully met its safety and efficacy goals at 3 months based on outcomes of transurethral resection typically performed in smaller prostates
  • Patient symptoms significantly improved with a decrease in International Prostate Symptom Score and an increase in maximum urinary flow rate
  • Regression analysis showed a 50% reduction in PSA levels
  • Aquablation demonstrated durable efficacy and low retreatment rates in men with large prostates (80-150 mL) at 5 years of follow-up
 

Attachments

Table 1. Baseline Demographics of the Initial WATER II Cohort and Those Available at 60 Months of Follow-up
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Figure 2. Longitudinal International Prostate Symptom Score (IPSS), IPSS quality of life (QOL), maximum urinary flow (Qmax), post-void residual (PVR), Male Sexual Health QuestionnaireeEjaculatory Dysfunction (MSHQ-EjD), and International Index of Erectile Function (IIEF-5) outcomes. CI indicates confidence interval.
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Figure 3. Change in prostate-specific antigen (PSA) as a function of baseline PSA at various time points of follow-up. The shaded area represents the 95% confidence interval (CI) for the best fit (solid) line.
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Figure 4. Longitudinal International Prostate Symptom Score (IPSS), IPSS quality of life (QOL), maximum urinary flow (Qmax), and post-void residual (PVR) outcomes comparing subgroup populations defined by baseline prostate size. CI indicates confidence interval.
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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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