Anyone have any experience with extremely high IGF-1 from overtraining?

AT1723

New Member
I am a 35 year old guy, with pituitary adenoma. The Dr. diagnosed GH secreeting tumor based only on my elevated IGF-1 and IGFBP-3 test results. I disagree with both this diagnosis and with the conclusion based only on IGF-1. I believe that the elevated IGF-1 is a result of my lifestyle.

IGF-1 is stable at 340 (range 80-242 - z score = 3)
IGFBP-3 is 5900 (range 2474 - 5208)
total test = in the range of 200-240 ng/dl for the last 2 years

I know I am crazy and stupid and compulsive with my training, I have lifted heavy 6 days a week for 14 straight months, also 15 sauna every day for 14 months. at least 3 days per week of heave 1RM squat and deadlift. needless to say that my gains have plateaued from both overtraining and low T.

Am I overtraining? (I think that is obvious), and can my elevated IGF-1 be explaining by my overtraining? I have found many research studies that show IGF-1 will skyrocket with prolonged heavy training.

Perhaps I should take like 2 weeks off and recheck IGF-1. maybe more time off?
 
Anything like an MRI(?) on the Pituitary to check for a tumor perhaps? Seems like the Adenoma could be better ruled in or out that way than the blood test.
 
Anything like an MRI(?) on the Pituitary to check for a tumor perhaps? Seems like the Adenoma could be better ruled in or out that way than the blood test.

I do have an 8mm pituitary adenoma (from the MRI), and zero leutenizing hormone. but no symptoms of acromegaly. I am going to request a glucose test for GH, because my morning GH blood tests showed very little growth hormone, but I know the blood tests are not a good indicator of elevated growth hormone.
 
Seems odd to me that IGF would be elevated from overtraining. I know I'm typically overtrained myself and when I've run IGF-1 it's been good or above mid-range, I don't know how to term it.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
3
Guests online
333
Total visitors
336

Latest posts

Back
Top