t_spacemonkey
Well-Known Member
Short-term consumption of sucralose with, but not without, carbohydrate impairs neural and metabolic sensitivity to sugar in humans - PMC
There is a general consensus that overconsumption of sugar sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no, or low-calorie “diet” ...
www.ncbi.nlm.nih.gov
The results from our studies demonstrate that LCS consumption produces metabolic dysfunction when it is consumed with, rather than uncoupled from, a carbohydrate. This implies that (a) carbohydrate metabolism is altered in the presence of the LCS sucralose and (b) that this alteration leads to decreases in peripheral and central sensitivity to sugar and sweet taste. Of particular relevance to the potential significance of this work, the metabolic changes observed following a very limited exposure that almost certainly occurs in freely living humans - especially if one considers the consumption of a diet drink along with a meal. This raises the possibility that the combination effect may be a major contributor to the rise in the incidence of type two diabetes and obesity. If so, the addition of LCS to increase the sweetness of carbohydrate containing food and beverages should be discouraged and consumption of diet drinks with meals should be counseled against.
