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The age-associated decline in sex hormone levels in men is paralleled by an increase in cardiovascular disease and associated risk factors including low grade chronic inflammation. The objective of this analysis was to investigate the association between sex hormone levels and C-reactive protein (CRP) in a population-based sample of men.
A multistage stratified design was used to recruit a random sample of 2,301 racially and ethnically diverse men age 30–79 years. Blood samples were obtained on 1,899 men. Analyses were conducted on 1,559 men with complete data on CRP and sex hormone levels. The association between CRP and sex hormone levels was assessed using multiple linear regression models.[h=3]Results[/b]
An inverse association was observed, in both bivariate and multivariate analyses, between CRP and total testosterone, free testosterone, and sex hormone-binding globulin (SHBG) levels. These associations remained statistically significant after adjusting for age, body mass index (BMI), comorbid conditions, and lifestyle factors. A positive trend between estradiol (total and free) and CRP levels was not statistically significant.
"Association of sex hormones and C-reactive protein levels in men," Clinical Endocrinology, 2010 April, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866020/
A multistage stratified design was used to recruit a random sample of 2,301 racially and ethnically diverse men age 30–79 years. Blood samples were obtained on 1,899 men. Analyses were conducted on 1,559 men with complete data on CRP and sex hormone levels. The association between CRP and sex hormone levels was assessed using multiple linear regression models.[h=3]Results[/b]
An inverse association was observed, in both bivariate and multivariate analyses, between CRP and total testosterone, free testosterone, and sex hormone-binding globulin (SHBG) levels. These associations remained statistically significant after adjusting for age, body mass index (BMI), comorbid conditions, and lifestyle factors. A positive trend between estradiol (total and free) and CRP levels was not statistically significant.
"Association of sex hormones and C-reactive protein levels in men," Clinical Endocrinology, 2010 April, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866020/
