Androgen Deprivation Therapy Increases Risk of Thrombosis

[Jinzang]

While lawyers and others argue whether testosterone augmentation increases the risk of thrombosis, there's new evidence that decreasing testosterone to combat prostate cancer significantly increases the risk. The news article says:

ADT (e.g. gonadotropin-releasing hormone agonists, antiandrogens) without estrogen increased the risk for thromboembolic events by a significant 43% in exposed versus unexposed patients, according to a meta-analysis of 10 studies including more than 250,000 men. The researchers found 10% and 58% greater risks among patients with localized and metastatic PCa, respectively. Nonsignificant results suggested that men who received ADT for more than a year were the most at risk. Investigators found no significant differences in risk between recipients of continuous and intermittent ADT.