Anabolic steroid use, brain health and dependence

madman

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Anabolic steroid use has been found to have negative effects on brain health, cognitive function, and mental health, particularly in long-term users and those who develop dependence.

Highlights

  • Anabolic steroids can lead to smaller brain volumes, reduced cortical thickness, and structural changes in the brain, impacting cognitive function.
  • Steroid dependence is associated with thinner prefrontal cortex, executive deficits, impaired social cognitive abilities, and personality pathology.
  • High prevalence of steroid use and dependence has been found in patients in treatment for substance use disorders.
  • Long-term steroid use is linked to accelerated brain aging and cognitive decline.
  • Non-dependent users generally do not show significant differences from weightlifting controls on most measures.
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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