Aduhelm: What you need to know about the new Alzheimer’s drug

[Nelson Vergel]

"Any side effects?
In two clinical trials, about 40% of clinical trial patients who got the approved dose of Aduhelm developed painful brain swelling. Symptoms included headache, dizziness, visual disturbances, nausea, and vomiting; about 17% to 18% of patients had microhemorrhages, or small bleeds in their brain. Patients will be monitored for brain swelling before their seventh and 12th infusions. If imaging shows severe swelling, treatment can continue “with caution only after a clinical evaluation and a follow-up MRI demonstrates radiographic stabilization,” the label says."

FAQs: What you need to know about the Alzheimer’s drug Aduhelm

 

[Nelson Vergel]

An extra twist in the FDA’s Alzheimer’s decision: no limits on which patients can get the drug

An extra twist in the FDA’s Alzheimer’s decision: no limits on which patients can get the drug

Doctors thought the FDA would limit who could get the new Alzheimer’s drug to certain early-stage patients — but it did no such thing.

www.statnews.com

 

[Nelson Vergel]

Alzheimer's disease drug development pipeline: 2021​

 

[Vince]

People with diabetes who didn't take metformin had a five times higher risk of developing dementia during the study, the investigators found. The researchers noted that this isn't the first study to show that metformin might be linked to lower dementia risk. Other studies have found a similar association.Sep 23, 2020
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Diabetes Drug Metformin May Protect Aging Brains - WebMD