9 years on Gel - Switch to Injection - Effect on HCT?

andro1percent

New Member
Hi, I've been on 1% Gel 1.25grams 4 pumps total for 9 years. Peaks are 2 hours after applying the gel. Generally in the upper 600's to low 700's total. Free is always in the upper portion of the range (13 to 15). HCT currently 43. SHBG and E1/E2 are both good as well.

My interest in switching to injection stems from the annoyance factor of applying the Gel every morning. Obviously after 9 years I've proven I can do it. And it's worked relatively well for me. But due to a few different factors I like the idea of not having to apply it anymore. My concern is the effect on HCT that it could have. However, in doing some research. It sounds like I may not experience much of a spike since I've been on Testosterone for so long. If I inject 2.5 times per week SUBQ it should further reduce the chance of a large HCT spike. I won't know until I try. But does anyone have experience doing this?
 
It depends on your dose. The thing about injections is that it's much too easy to overdose, and most men do. For example, the common starting dose of 100 mg of testosterone cypionate per week is well above typical healthy natural production, which is equivalent to more like 50-70 mg.

Regarding the switch to cypionate in general, on the minus side, you may lose some daily variation in testosterone levels—assuming you're getting some with the gel. It's possible there are some benefits in these variations. On the plus side, your DHT may be more in balance with other hormones, as topical testosterone tends to send it quite high.

The good thing is that you have a well-established baseline; presumably you'll be able to tell if things start going downhill. Bear in mind that if you do take in more testosterone than currently then you could have a honeymoon period in which you feel pretty amazing. But such periods typically don't last and you could still end up worse off. If you go this route I recommend a low-and-slow approach. Start at 50-60 mg TC/week and only increase a little at a time if needed.
 
The gel seems to work well for you. Did you also test the trough T level?
You can always go back to gel if the injections turn out to be inferior.
If the gel is androgel 1%, you could switch to androgel 1.6%, so that you need only 2-3 pumps of gel instead of 4 pumps and benefit from quicker application of the gel.
Or you can combine sc injections with gel.

If you want to minimize injections, I can recommend testosterone undecanoate. One injection per week.
 
Hi, I've been on 1% Gel 1.25grams 4 pumps total for 9 years. Peaks are 2 hours after applying the gel. Generally in the upper 600's to low 700's total. Free is always in the upper portion of the range (13 to 15). HCT currently 43. SHBG and E1/E2 are both good as well.

My interest in switching to injection stems from the annoyance factor of applying the Gel every morning. Obviously after 9 years I've proven I can do it. And it's worked relatively well for me. But due to a few different factors I like the idea of not having to apply it anymore. My concern is the effect on HCT that it could have. However, in doing some research. It sounds like I may not experience much of a spike since I've been on Testosterone for so long. If I inject 2.5 times per week SUBQ it should further reduce the chance of a large HCT spike. I won't know until I try. But does anyone have experience doing this?
Have you ever measured through levels in the morning, assuming you only apply in the morning?
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
3
Guests online
190
Total visitors
193

Latest posts

Back
Top