2024 Partnership for the Accurate Testing of Hormones (PATH) Annual Committee Meeting

madman

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On April 25, 2024, the Division of Laboratory Sciences (DLS) Clinical Standardization Programs (CSP) team in the Clinical Chemistry Branch participated in the 2024 Partnership for the Accurate Testing of Hormones (PATH) annual committee meeting.

PATH works to strengthen partnership engagement to improve laboratory tests for chronic disease biomarkers and to increase awareness of quality in clinical laboratory testing. In addition, PATH provides educational activities and toolkits for clinicians and public health on the importance of accurate and reliable laboratory tests and the public health benefits when standardized tests are used.

DLS Director Dr. Benjamin Blount was a guest speaker and shared DLS’ longstanding commitment to standardizing laboratory testing, which dates back to the 1950s with the standardization of lipid and lipoprotein measurements. Drs. Alicia Lyle, Uliana Danilenko, and Hubert Vesper from CDC CSP presented data on the status of analytical performance of vitamin D tests currently being standardized, and of free testosterone and parathyroid tests in need of standardization.

The 2024 hybrid annual meeting drew more than 30 participants in person and online and featured presentations from the American Thyroid Association Committee of Laboratory Services, Association for Diagnostics & Laboratory Medicine – Science and Practice Core Committee, and Polycystic Ovary Syndrome Challenge.
 


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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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