2 Injections Per Week, Back to 1?

[Westin]

I have been at 2 x 50mg per week for over a year with Ok results. When I was at 100mg once per week I did have a couple days per week where things were working great.

Question: If I went back to 1 time weekly at 100mg and even raised it to 110, could I recapture that "great" coupe days?

Also, what would going from 50mg X 2 weekly to 1 X 100mg or 110mg do to hematocrit? I'm 60 years old, HCT 47.5, top end of scale is 51. I really need to keep an eye in the blood having just quit smoking.

Just curious.

 

[madman]

I have been at 2 x 50mg per week for over a year with Ok results. When I was at 100mg once per week I did have a couple days per week where things were working great.

Question: If I went back to 1 time weekly at 100mg and even raised it to 110, could I recapture that "great" coupe days?

Also, what would going from 50mg X 2 weekly to 1 X 100mg or 110mg do to hematocrit? I'm 60 years old, HCT 47.5, top end of scale is 51. I really need to keep an eye in the blood having just quit smoking.

Just curious.

Once weekly IM injections using higher doses of T will result in a significant difference peak--->trough.

Post-injection T levels will start rising within the first 2 hours (initial burst release) peaking 8-12 hrs and remain elevated during the first few days only to be followed by much lower levels come week's end.

Some men tend to do well on once-weekly injections as they tend to feel better early in the week when T levels are higher let alone still feel descent come week's end if trough level is still healthy.

Others not so much as unstable T levels throughout the week can have a negative impact on mood, energy, libido, erectile function, recovery.

Good chance that if you switch to once-weekly injections you will most likely feel great during the weeks leading up until blood levels stabilize (4-6 weeks) as the body is trying to adjust but even then once blood levels have stabilized it will take another 2-3 months for the body to fully adapt to those new levels.

No one can say for sure how you will feel during this time as only time will tell.

Chances are if you felt descent overall previously then you may end up doing well and doubtful you would need to increase your dose from 100-110 mg/week to achieve such unless your trough TT was too low.

Downfall would be that when it comes to elevated RBCs/hemoglobin/hematocrit once-weekly injections can result in very high supra-physiological levels post-injection let alone will have a big impact on peak--->trough.

Even then when it comes to elevated hematocrit much more is involved.

T formulation, the dose of T, genetics (polymorphism of the AR), age all play a role in the impact a trt protocol will have on blood markers (RBCs/hemoglobin/hematocrit).

Other factors such as sleep apnea, smoking can have a negative impact on hematocrit.

Injectable T has been shown to have a greater impact on increasing HCT compared to transdermal T.

3–18% with transdermal administration and up to 44% with injection.

In most cases when using injectable T high supra-physiological peaks post-injection and overall T levels (running too high TT/FT level) will have a big impact on increasing HCT.

Manipulating injection frequency by injecting more frequently using lower doses of T resulting in minimizing the peak--->trough and maintaining more stable levels may lessen the impact on HCT but it is not a given.

As again running very high TT/FT levels will have a stronger impact on driving up HCT.

Although injectables have been shown to have a greater impact on HCT you can see even when using a transdermal formulation that maintains stable serum concentrations that the impact it has on HCT is DEPENDANT ON THE DOSE AND SERUM LEVEL OF T.

Using higher doses of transdermal T and achieving higher TT/FT levels will have a great impact on HCT levels.

*How high an FT level you are running is critical

It is a given that most men on trt struggling with elevated RBCs/hemoglobin/hematocrit are running too high an FT level.

Sure some men are more sensitive than others as they may still struggle with elevated blood markers when running lower T levels but it is far from common and many may already have an underlying health issue contributing to such.

*If you are struggling with such blood markers then in most cases finding the lowest FT level you can run while still maintaining the beneficial effects may very well be the solution

Easier said than done as many men on trt tend to do better running higher-end FT levels within reason.

Mind you some are lucky and never have an issue or levels tend to stabilize over time.

Others will continue to struggle until the cows come home.

Unfortunately too many are caught up in running absurdly high trough FT levels due to the herd mentality spewed on the bro forums and gootube!

Other options would be hCG monotherapy (achieve physiological T levels), Natesto (short-lived peaks (800ng/dL)/long trough time between doses), T patch (most closely mimics natural 24hr circadian rhythm/mid-range T levels).

 

[Vince]

I have been at 2 x 50mg per week for over a year with Ok results. When I was at 100mg once per week I did have a couple days per week where things were working great.

Question: If I went back to 1 time weekly at 100mg and even raised it to 110, could I recapture that "great" coupe days?

Also, what would going from 50mg X 2 weekly to 1 X 100mg or 110mg do to hematocrit? I'm 60 years old, HCT 47.5, top end of scale is 51. I really need to keep an eye in the blood having just quit smoking.

Just curious.

The only way you would truly know if once weekly injections, helps. Is by trying it. So my personal opinion would be go for it, what do you got to lose.