0.25mg oral Finasteride daily - risk of Post-Finasteride Syndrome?

davidandrade · Saturday at 4:37 PM

Hi All,

Can taking 0.25mg of oral Finasteride daily still pose a risk for Post-Finasteride Syndrome? Starting to lose hair on my crown and all the way down the middle of my head towards my forehead. I was thinking of cutting a 1mg Finasteride tablet into quarters and only taking 0.25mg a day which some studies have shown to be almost as effective as 1mg a day with fewer side effects. I'm just wondering if such a low daily dose would still pose a risk for Post-Finasteride Syndrome?

Are there any natural DHT blocking alternatives that have worked for you? Some I have heard mentioned are:
1.Saw Palmetto
2. Pumpkin seed oil
3. EGCG (green tea)
4. Rosemary oil
5. Ketoconazole shampoo 2 to 3 times a week

Thanks for your input!

madman · Saturday at 5:47 PM

davidandrade said:
Hi All,

Can taking 0.25mg of oral Finasteride daily still pose a risk for Post-Finasteride Syndrome? Starting to lose hair on my crown and all the way down the middle of my head towards my forehead. I was thinking of cutting a 1mg Finasteride tablet into quarters and only taking 0.25mg a day which some studies have shown to be almost as effective as 1mg a day with fewer side effects. I'm just wondering if such a low daily dose would still pose a risk for Post-Finasteride Syndrome?

Are there any natural DHT blocking alternatives that have worked for you? Some I have heard mentioned are:
1.Saw Palmetto
2. Pumpkin seed oil
3. EGCG (green tea)
4. Rosemary oil
5. Ketoconazole shampoo 2 to 3 times a week

Thanks for your input.

It will still have a strong suppressive effect on scalp skin/serum DHT.

No one can say how you will react and chances are you may very well run into sides especially when it comes libido, erectile function and ejaculate volume.

My reply from another thread.

Keep in mind when it comes to MPB/AGA your chance of accelerating such when using exogenous T comes down to genetics and sensitivity of the AR/hair follices to DHT.

Important point often overlooked here is that high DHT is not always needed as again it comes down to the sensitivity of the AR/hair follices to DHT.

Would tread lightly when it comes to f**king with 5AR inhibitors let alone AIs as Ts metabolites estradiol and DHT are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects on (cardiovascular health, brain health, libido, erectile function, bone health, tendon health, immune system, lipids, and body composition).

I would also stay away from any of those alternatives some of which can act as mild 5-ARIs.

Playing with the devil's candy can have dire consequences for many especially the genetically prone individuals suffering with PFS!

* Finasteride —or Propecia, its most well-known brand name— is a medication taken by millions of men hoping to slow down hair loss. Yet this product is not without risk: over the past fifteen years, regulatory authorities have added numerous warnings about potential sexual dysfunction and depression, rare side effects that can persist for years after stopping treatment. At the heart of the controversy: allegations that Merck, the drug’s manufacturer, knew of these risks but chose to downplay them, in order to maximize profits.

Thread 'Post-finasteride syndrome - a true clinical entity?'

Feb 28, 2025

This review critically examines Post-Finasteride Syndrome (PFS), a condition eventually reported by men who have used finasteride for androgenetic alopecia or benign prostatic enlargement and experienced persistent adverse effects after discontinuation. We explore the clinical manifestations, including sexual dysfunction, neuropsychiatric symptoms, and physical changes, that collectively challenge both diagnosis and management. This review evaluates the evidence for PFS, discusses potential mechanisms including neurobiological alterations, genetic predispositions, and...

madman · Saturday at 5:56 PM

* The most common side effects of 5-ARIs include impotence, decreased libido, ejaculatory disorders, and gynecomastia.14 Less common side effects that have been reported include infertility, breast tenderness, depression, anxiety, dementia, and suicide. 15-18

Thread 'The clinical applications of 5ARi's'

Apr 21, 2021

Introduction:

Five-alpha reductase (5-AR) deficiency was first identified by Imperato-McGinley and Walsh as the cause of pseudohermaphroditism in two separate studies. The discoveries led to the development of finasteride (inhibitor of type 2 isoenzyme of 5-AR) and dutasteride (inhibitor of type 1 and type 2 isoenzymes of 5-AR.

Both drugs have been proven effective for the treatment of benign prostatic hyperplasia and improve voiding symptoms, reduce the risk of urinary retention, and the need for prostate surgery.

Five-alpha reductase inhibitors 5-ARIs have...

davidandrade · Saturday at 6:11 PM

madman said:
It will still have a strong suppressive effect on scalp skin/serum DHT.

No one can say how you will react and chances are you may very well run into sides especially when it comes libido, erectile function and ejaculate volume.

My reply from another thread.

Keep in mind when it comes to MPB/AGA your chance of accelerating such when using exogenous T comes down to genetics and sensitivity of the AR/hair follices to DHT.

Important point often overlooked here is that high DHT is not always needed as again it comes down to the sensitivity of the AR/hair follices to DHT.

Would tread lightly when it comes to f**king with 5AR inhibitors let alone AIs as Ts metabolites estradiol and DHT are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects on (cardiovascular health, brain health, libido, erectile function, bone health, tendon health, immune system, lipids, and body composition).

I would also stay away from any of those alternatives some of which can act as mild 5-ARIs.

Playing with the devil's candy can have dire consequences for many especially the genetically prone individuals suffering with PFS!

* Finasteride —or Propecia, its most well-known brand name— is a medication taken by millions of men hoping to slow down hair loss. Yet this product is not without risk: over the past fifteen years, regulatory authorities have added numerous warnings about potential sexual dysfunction and depression, rare side effects that can persist for years after stopping treatment. At the heart of the controversy: allegations that Merck, the drug’s manufacturer, knew of these risks but chose to downplay them, in order to maximize profits.

Thread 'Post-finasteride syndrome - a true clinical entity?'

Feb 28, 2025

This review critically examines Post-Finasteride Syndrome (PFS), a condition eventually reported by men who have used finasteride for androgenetic alopecia or benign prostatic enlargement and experienced persistent adverse effects after discontinuation. We explore the clinical manifestations, including sexual dysfunction, neuropsychiatric symptoms, and physical changes, that collectively challenge both diagnosis and management. This review evaluates the evidence for PFS, discusses potential mechanisms including neurobiological alterations, genetic predispositions, and...

madman

post finasteride syndrome

Replies: 9

Forum: When TRT Is Not Enough (ED, Libido, & More)

Great advice madman! I am going to stay away from the Finasteride.

Guided_by_Voices · Saturday at 10:44 PM

I have recently started using red light therapy for joint issues and in reading about it, it seems to have a pro-hair affect as well. I use the $90 face mask sold on amazon but it is a flexible mat that you can form to use almost anywhere including the top of your head. Also, there have been a variety or reports over the years of some peptides like the copper peptides having a pro-hair affect, but I've never really pursued that since Thankfully) my hair is fairly stable, but that is something to look into. They are typically applied with a sort of derma-roller that makes tiny incisions in your scalp.

Kenp · Sunday at 5:15 AM

Use needling + minox for hairloss. And save up for a possible transplant in the future but stay away from ANY 5ari.

Systemlord · Sunday at 1:39 PM

Some people don’t develop PFS until after they taper off the medicine. There’s a protocol for coming off, which is very high dose testosterone, injectables and creams to boost DHT very high.