ssri

  1. Seagal

    Effects of selective serotonin reuptake inhibitors on endocrine system

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273194/ https://pubmed.ncbi.nlm.nih.gov/28179152/
  2. A

    anyone take TRT alongside mental health medications like Prozac(SSRIs) and Adderall or vyvanse?

    I hear many people have success stories with mental health when it comes to TRT. Im not going to lie, my mental health has been rough recently. I have been thinking about biting the bullet on seeing a psychiatrist and getting an SSRI prescribed. Is there anyone here on TRT and also on...
  3. Seagal

    Serotonin SSRI appetite regulation and beyond

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408233/
  4. J

    Reassessing Serotonin

    From Jay Feldman
  5. T

    Did SSRI's cause problems for your TRT protocol?

    I've read about SSRIs have some effect on various sex hormones. I've started recently Zoloft for anxiety but can't help but feel like it's doing weird things to my hormones. This isn't my first time on Zoloft, I have been on it in the past but when prior to TRT. Is anyone here on TRT with and...
  6. D

    TRT + Low Dose SSRI ...anyone doing this protocol?

    Most of us have probably seen one of the many threads by @madman which are great for explaining PSSD (Post-SSRI sexual dysfunction). However, this post targeted towards using a VERY low dose ssri for helping with allopregnenolone issues. There is an existing thread on this topic but I just...
  7. T

    The serotonin theory of depression: a systematic umbrella review of the evidence (20 July 2022)

    It is often assumed that the effects of antidepressants demonstrate that depression must be at least partially caused by a brain-based chemical abnormality, and that the apparent efficacy of SSRIs shows that serotonin is implicated. Other explanations for the effects of antidepressants have been...
  8. G

    Ssri discontinued/libido ED problems

    I’ve been on T for two and a half years now with inconsistent libido (the cream being more beneficial than shots). Before I got on trt my sexual function was fine. Last year I took an ssri for about six months. I stopped taking it two months ago because I thought my ED was from the drug but I’m...
  9. N

    TRT was going great!

    All in all I’ve been in doctor prescribed TRT for over two years now. I’ve been with defy for about a year now, the majority of the last year year has been fantastic since dealing with doctors that really know their shit. I went through a break up this spring and my doctor put me on Zoloft, I...
  10. Vince Carter

    Docu: Letters from Generation Rx

    Currently on Amazon Prime...focuses on SSRI's and psychosis/psychotic episodes/suicide of those taking the drugs such as Paxil/Zoloft/Prozac/et al..,
  11. S

    Optimal TRT Strategy for low SHBG guys; SSRI effects; HCG vs. T injections effect on polycythemia

    Hi everyone, I've been reading here for a little over a year and I've found this site most educational. Thank you to Nelson for all the informative material on this website (I also enjoyed your book which I bought on Amazon) and for everyone else here who contributes information and shares...
  12. N

    Antidepressants hormonal effect

    I've recently stopped taking an SSRI (escitalopram) and have since noticed high estrogen symptoms. Is there any evidence and/or experience that this drug or dru class can effect estrogen levels or estrogen response?
  13. C

    4 weeks on TRT - anxiety advice

    Hey everyone, I had an appointment with Dr. Saya at the beginning of Nov. and have been on Testosterone Cypionate 70 mg and 3.5 ml of HCG every 3.5 days (2x week, so 140 mg t-cyp) since then (4 weeks). So, I have had anxiety problems most of my life (that are hereditary) and had been on...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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