Hcg + Trt

HCG (human chorionic gonadotropin) is used alongside testosterone replacement therapy to preserve testicular size, maintain intratesticular testosterone, and support fertility by mimicking luteinizing hormone. Common protocols range from 250 to 500 IU two to three times per week, with clinical data showing 500 IU every other day can maintain sperm parameters during TRT. Discussions in this tag cover real dosing experiences, subq vs IM injection, timing around testosterone shots, effects on libido and mood, sourcing after the 2020 biologics reclassification, and how men adjust the balance between testosterone and HCG over time.
  1. Nelson Vergel

    hCG Plus TRT Testicular & Fertility Restoration Protocol

    This document synthesizes key findings on the use of Human Chorionic Gonadotropin (hCG) in men, either as an adjunct to Testosterone Replacement Therapy (TRT) or as a standalone monotherapy. By mimicking the body's Luteinizing Hormone (LH), hCG directly stimulates the testicles, offering a...
  2. R

    Incremental increase in Testosterone levels by adding HCG it TRT

    Does anyone have data or experience on the incremental increase in testosterone levels achieved by adding HCG to TRT with IM/SQ Testosterone? For example, if Total T increases from a baseling of 300 to a nadir of 600 using 100 mg per week of TC, and then HCG is added, what would one expect with...
  3. B

    Arimidex daily vs twice weekly

    Currently I am on TRT: 16mg Test Cyp Daily SubQ 250iu HCG every 3.5 days 0.125mg arimidex 12 and 24 hours post HCG shot I am running HCG purely for neurosteroids, libido, ED. Without HCG I have debilitating brainfog, chronic mental fatigue, and lousy sex drive on TRT without it. I run minimal...
  4. Nelson Vergel

    Can Clomiphene / Enclomiphene Reverse Testicular Atrophy? Review of Limited Data.

    Below is a synthesis of what the literature presently shows about clomiphene (and its trans-isomer enclomiphene) and reversal of testicular atrophy in men. What hard data exist? Setting Study design (n) Testicular-volume result Time to observation Secondary hypogonadism, enclomiphene 25...
  5. Nelson Vergel

    Why Use hCG With TRT?- A Clinical Review

    Using hCG in Men on Testosterone Replacement Therapy (TRT) – A Clinical Review Introduction Exogenous testosterone replacement therapy (TRT) can profoundly suppress the hypothalamic-pituitary-gonadal (HPG) axis through negative feedback. By inhibiting gonadotropin-releasing hormone (GnRH) and...
  6. P

    Testogel and HCG

    Hi all and thanks in advance. Ive been using Testogel forn4 months and I am pleased with the results.But I really hate the testicular atrophy.Would twice weekly 250iu of HCG help with this ? I've also been looking at the premixed pens as this seems an easier way to administer. I'd be really...
  7. Shaunnn

    HCG while on TRT for testicular atrophy

    Hi, i am new to the site. I have been on TRT for a year and my boys have shrunk significantly. When I climax during sex? The amount is maybe a 1/4 of what it wss before TRT. I've read that clomiphene and HCG can help reverse testicular atrophy. To take HCG wpuld I have to stop TRT or can it...
  8. T

    Strating hcg after being on trt 2 years

    Hcg. I have been on testosterone cream for 2 years. I didn't use hcg because done having kids. However my testicles have shrunk so much and almost non-existent. I am thinking of going on hcg I hopes of testicals growing again after two years is this irreversible of will hcg help? Also does...
  9. V

    HCG to combat testicular atrophy and low libido

    Hello, 68 yo male, HIV+ here. I foolishly have been on TRT for over 20 years with never cycling off of it or using HCG with it. Needless to say, my testicular atrophy has gotten very severe. Also, for unknown reasons I have completely lost my libido in the past year. That has never been a...
  10. S

    Discontinue HCG on Trt lower testosterone levels ?

    Would discontinuing HCG while on TRT lower my testosterone levels?
  11. D

    Minimum Effective Dose of HCG Weekly To Prevent Testicular Atrophy

    Human Chorionic Gonadotropin (From the book Testosterone: A Mans Guide, amazon.com) Human chorionic gonadotropin (HCG) (not to be confused with human growth hormone, or HGH) is a glycoprotein hormone that mimics LH (luteinizing hormone), produced in pregnancy by the developing embryo soon after...
  12. N

    HCG timing with 1x week testosterone injections

    Honestly have been feeling a bit better with 1x a week injections instead of 2 (cyponiate). Regarding my HCG timing, should I try doing that more towards the end of the week? For instance, cyponiate on Monday, HCG on Thurs and Friday type of thing? To maybe counteract the trough?
  13. D

    Considering adding hCG, questions about e2 and mood

    I've been pretty stable on test cyp for a couple years now. I'd like to regain some testicle size which got me thinking about adding hCG. I've also heard people say it can improve mood which I'd be interested in. Can anyone share specifics of mood improvements? Does adding hCG affect estrodial...
  14. BJE

    Alternatives to HCG for preventing testicular atrophy.

    HCG has worked well for me to keep my testicles up to size. However, it has gotten more expensive and sometimes unavailable. Is there any other strategy to keep them large?
  15. phalloguy100

    Why is it a bad idea to take clomid/gonadorelin while on TRT?

    I have read in this and other forums that taking clomid, gonadorelin, or kisspeptin while on TRT is a waste - that those things are used more for PCT, to regain testicular function. But why is it wasteful, or even contraindicated, to use those medications while on TRT? How does one harm the...
  16. G

    How much HCG should I take with testosterone?

    Hello everybody, I am 50 years old, on TRT for 15 years. My treatment protocol is 100mg Testosterone enathate per week (subcutaneous, EOD). I'd like to include HCG in my protocol. My question is how much HCG should I take and how much Testosterone ena. should I reduce in order to keep the same...
  17. L

    Dr. John Crisler HCG T protocol in its entirety

    This protocol FYI is very difficult to find now that Dr. Crisler has sadly passed on due to suicide. Here it is in its entirety for those who have not seen it before: Crisler HCG protocol By John Crisler, DO In my paper “My Current Best Thoughts on How to Administer TRT for Men”, published...
  18. S

    New member, hcg ovitrelle overdose

    Hello, i got prescribed pen hcg ovitrelle 6500 iu(it should last me for month) Doctor told me to inject 3x 780 iu a week. First day (yesterday) i took 2860iu shot by mistake ( first time using pen - wrong calculation ). Should i wait couple days before resuming injections ? In my country its...
  19. bray

    Doc prescribed HCG and Test C

    Hi, this is my first post here I hope I have found the correct sub forum. I recently got diagnosed low T and will start late next week. During my consultation I was asked what treatment I was looking for and I said just testosterone eod as I am adamant I don't want kids and neither does my...
  20. N

    Gonadotrope hcg vs fertigyn hcg from india question

    So I have been using gonadotrope brand hcg (don't know if I'm allowed to post source ) that seems to work VERY well. I have recently after some research and conversations with people on here have acquired some fertigyn hcg that's supposed to be one of the better Indian hcg brands. Is there...
  21. K

    Anastrazole timings - twice a week or each time I inject?

    Hi there I posted a few months ago and took the advice to lower my dosages - thanks to those who advised. Currently on Sustanon, HCG and Anastrazole. This message isn't to have a debate on whether or not AIs are good or bad - we're all different and I understand that @Nelson Vergel doesn't want...
  22. F

    HCG pre-mixed instead of powder??

    I recently bought some Bharat Serums brand HCG 5000iu. Surprise!!! It came as liquid in 5000iu vial, not a powder kit. Last time I bought that brand it was vial of powder, and sterile water separate, worked great. My doc said that shipping mixed product is very bad. Any shaking in shipment...
  23. W

    HCG - Dud vial?

    For anyone who remembers the start of their HCG... How long was it before you first started noticing anything from the start, And what was it you noticed specifically? I have started 500iu every 3rd day and feel nothing these last two weeks. I purchased zyhcg from India. I don't know if it's a...
  24. O

    HCG and DHEAs

    How much time after starting HCG should we test for DHEAs and serum estradiol to check if it has any effect on it ? Considering 500iu EOD of HCG .
  25. G

    Quitting TRT after low dosage of T

    Hi. I have quit TRT after a year of low dosage of T (50 MG a week), which was with some HCG type testicle stimulating therapy. Do I still need clomid and anestosole TRT quitting therapy if a week after quitting my LH is 17 (1-25 norm) and my FT is 6 (9-21)? My pre trt FT had been 9.
  26. R

    Where to buy my HCG ?

    Where is the most affordable and reputable place to purchase a 10,000 iu bottle of HCG? Prefer places only in the the United States.
  27. jacb

    HMG (Human Menopausal Gonadotropin) Vrs HCG (Human Chorionic Gonadotropin) - What’s the difference?

    I was just watching a video on YouTube titled: ”The Pro's & Con's Of HCG On Cycle | Desensitisation | Testicular Volume | Semen Volume | Fertility”. Video Link The speaker who appears to understand the subject much better than I do introduced HMG (Human Menopausal Gonadotrophin) which he...
  28. Nelson Vergel

    The Continued Use of Testosterone Does Not Interfere with Human Chorionic Gonadotropin (hCG) -Mediated Return of Spermatogenesis

    In the realm of reproductive health, one of the most challenging puzzles has been how to balance the benefits of testosterone therapy with the desire to maintain or restore fertility in men. A recent study published in The Journal of Sexual Medicine, led by J Kassab and team, sheds new light on...
  29. phalloguy100

    Getting sleepy after T-cyp injections?

    I was on Androgel until last year, when it seemingly stopped absorbing so i was switched to compounded cream. Well, it worked great for two weeks, but then it wouldn't absorb consistently either. So the doctor switched me to T-Cyp in grapeseed oil, which I started last week. I'm now doing T-cyp...
  30. Marchickney

    TRT - YEAR 1 REVIEW & RESULTS - HOW LOW CAN YOU GO ?

    Hi Guys, Engineer NERD Alert - This post contains Tmi personal lol be warned :cool: Thought I would share my data as it might help others treading similar path. Although I hope No one is as unlucky as me and has a near death motorcycle crash with a TBi , learn from my mistakes and don't go...
  31. D

    Lower TRT dosage when adding hCG to keep blood work stable?

    Hi All, I'm adding hCG to my TRT regimen in hopes it will clear up some brain fog issues and improve my libido. Since I'm happy with all of my current hormone levels, and don't want them to change, should I decrease my TRT dosage by some amount when I start the HCG? Current levels and meds...
Defy Medical TRT clinic

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Hcg + Trt

Hcg + Trt HCG (human chorionic gonadotropin) is used alongside testosterone replacement therapy to preserve testicular size, maintain intratesticular testosterone, and support fertility by mimicking luteinizing hormone. Common protocols range from 250 to 500 IU two to three times per week, with clinical data showing 500 IU every other day can maintain sperm parameters during TRT. Discussions in this tag cover real dosing experiences, subq vs IM injection, timing around testosterone shots, effects on libido and mood, sourcing after the 2020 biologics reclassification, and how men adjust the balance between testosterone and HCG over time.

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