flavonoids; varicose veins; chronic venous

Effectiveness of micronized purified flavonoid fraction on venous symptoms and signs in patients at all stages of chronic venous disease: a systematic review and meta-analysis (2025) Andrew NICOLAIDES, Kirill LOBASTOV, Armando MANSILHA, Alejandro J. GONZALEZ-OCHOA, Vanessa BLANC-GUILLEMAUD...

Do your legs feel heavy, achy, or swollen by the end of the day? Have you noticed bulging varicose veins or skin changes near your ankles? These could be early warning signs of chronic venous insufficiency (CVI) — a condition where the valves in your veins stop working properly and blood pools...

* In symptomatic chronic venous disease patients, MPFF 1000 mg once daily and MPFF 500 mg twice daily improve patient compliance, lower limb discomfort, clinical adverse events, and quality of life scores similarly. Abstract Background Micronized purified flavonoid fraction (MPFF) is...

MPFF (Micronized Purified Flavonoid Fraction) is a well-researched combination of bioflavonoids, including Diosmin and Hesperidin. For 40 years, it has been studied for its role in supporting venous and lymphatic function. Dr. Chuback breaks down how MPFF works and why it holds a 1A...

New Perspectives on Micronised Purified Flavonoid Fraction in Chronic Venous Disease: From Microvalves to Clinical Effectiveness (2022) Eliete Bouskela . Marzia Lugli . Andrew Nicolaides ABSTRACT The importance of chronic venous disease (CVD), as a cause of reduced quality of life and...