1. #1
    Super Moderator Nelson Vergel's Avatar
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    Rekynda (bremelanotide) for Female Sexual Disorder

    Rekynda (bremelanotide), an investigational product, is thought to possess a novel mechanism of action, activating endogenous melanocortin pathways involved in sexual desire and response.

    The two Phase 3 studies for HSDD in pre-menopausal women consisted of double-blind placebo-controlled, randomized parallel group studies comparing a subcutaneous dose of 1.75 mg Rekynda delivered via an auto-injector pen to placebo. Each trial consisted of more than 600 patients randomized in a 1:1 ratio to either the treatment arm or placebo with a 24 week evaluation period. In both clinical trials, Rekynda met the pre-specified co-primary efficacy endpoints of improvement in desire and decrease in distress associated with low sexual desire as measured using validated patient-reported outcome instruments.



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    May offer some promise as an adjunct for post-menopausal women (wouldn't offer some of the health benefits of appropriately administered BHRT) or as standalone treatment for premenopausal females with HSDD not needing BHRT. They are developing it as an "as needed" libido/arousal/function booster similar to "as needed" viagra.

    This compound is the same as the peptide PT-141 (still available through some of the research peptide sites) and was isolated from melanotan (another research peptide).

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