1. #1
    Junior Member
    Join Date
    Apr 2018
    Chicago area

    Back on Pregnenolone - Interesting Consequences

    I started back up with Pregnenolone, with some interesting effects.

    I had taken pregnenolone in the past, (years ago) 50 mg, it seemed to have no effect at that time, but now it does.

    This is the problem with many supplements/hormones, they are syngeneic with other hormones supplements. I have been taking boron 6-9 mg daily and now my vit D was raised from 25 > 46 ng/mL (last tested in Jan) (30-100 ng/mL), they may have played a role in how I react.

    Anyway ...

    Starting at 50 mg preg, I slept much better, and felt calm the next day, it seems like I went from mild constipation to loose stools, and I feel like I am a little more likely to get a muscle cramp. However, the second day I was sleeping off and on all day long.

    So I lowered by dose to 12.5 mg, still slept well, but not so sleepy the next day, still feel more calm, my pulse rate may have dropped from 65 to 57, hard to tell without more monitoring.

    Time will tell on the sleep aspect, I usually fall asleep easily, but I am also a very light sleeper and wake up at least once to 3-4 times a night, often I will be up for an hour. Time will tell because sleep is so tricky, what helps for a few days seems to wear off after a short time.

    I have never measured pregnenolone levels, I have read serum levels of preg will peak 3 hours after oral ingestion, and from Wikipedia:

    Oral administration of 50 or 100 mg pregnenolone has been found to have minimal or negligible effect on urinary levels of testosterone and testosterone metabolites, including of androsterone, etiocholanolone, 5β-androstanediol, androstadienol, and androstenol (and/or their conjugates), and this suggests that only a small amount of pregnenolone is converted into testosterone.[17][18] This is in accordance with findings on the conversion of DHEA into testosterone, in which only 1.5% of an oral dose of DHEA was found to be converted into testosterone.[17] In contrast to the androstanes, 50 or 100 mg oral pregnenolone has been found to significantly and in fact "strongly" increase urinary levels of the progesterone metabolites pregnanediol and pregnanolone (and/or their conjugates), whereas pregnanetriol was unaffected.[17][18] Unlike the case of oral administration, transdermal administration of 30 mg/day pregnenolone cream has not been found to affect urinary levels of metabolites of any other steroids, including of progesterone.[18]


    As I say, interesting, I will continue with pregnenolone, see if any of these effects are long lasting and maybe lower to dose from 12.5 mg.

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  3. #2
    So is there really any difference between taking DHEA or Pregnenolone? They both go down the same hormonal pathway so wouldn't their affects be the same? If there is a difference between them what is it? I took 30 mg of preg today and it gave me a ton of energy, stamina, and aggression in the gym.

    Last edited by JayLay777; 06-11-2018 at 08:04 PM.

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