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38M who has been on TRT + HCG for ~5 years or so. I wanted to see if I could restart production with the help of enclomiphene, as prior to TRT I had a great response to clomid but could not handle the estrogen related sides. I started 12.5mg ED about a month ago, and just got back labs from a...

I wanted to crowdsource some thoughts on erection issues I'm having. Background I am 33 years old, generally healthy Started TRT at age 28 - after symptoms, discovered a pituitary tumor and T levels in the 100s. Ruled out primary hypogonadism. TRT has done wonders for my physical appearance...

Have struggled with libido and ED despite a well tuned TRT regimen. Injected 1.5 mg of PT-141 at 5:30 PM today. The script says 1-2mg, so I went right down the middle. It took forever to work, probably 4-5 hours (script said 45 minutes) but it gave incredible and lasting erections with the...

I have historically injected sub-q via the fat above my hips, but recently have been bruising a lot and bleeding there, so I began to inject sub-q in my quads. I didn't connect the dots at the time, but around the same time began to feel like I had crashed my E2 as I could not get an erection...

Wanting to pick some brains here to see if there's something I'm missing. I am 35 years old, 6'2", 216 lbs and am on a stable TRT protocol due to a pituitary mass that left me with secondary hypogonadism 5 years ago or so. I cannot seem to lose weight over the past year or so; in fact, my...

I’ve been on a stable TRT protocol for a few years. Recently, I’m experiencing: -Red face (doesn’t feel flushed or hot, people just say it’s red) - Wake up in AM with sweat around my neck but am not hot - Generally insensitive to heat - lots of sweat and run A/C constantly to my wife’s...

Does anyone experience throat tightness with Cialis? I can’t find a cause for this so I’m methodically removing foods, meds, etc., to see what could be causing it - and it seems there may be a link to my daily Cialis. Cialis gives me acid reflux also, so I’m wondering if the reflux is what’s...

Guys - realize this is a long read. Hoping for some help. I am 33 years old and have been on a stable TRT protocol for 3 or so years now. Recently, I’m progressively unable to achieve a solid erection. In my most recent consult in March, my doctor (who is great and well respected here) added...

I have been on a stable TRT protocol administered by one of the more reputable physicians often mentioned on this forum, but have been chasing ED issues since the beginning. Most recently, I was having issues getting physically aroused, and would lose my erection during intercourse, which is...

I’ve used EAS Myoplex over the years as a meal replacement, mainly for lunches where I can’t get away from my desk. I just found out that it’s been recently discontinued, and am looking for suitable replacements. Any suggestions? I liked how the Myoplex formula was well-balanced, including...

For those of you taking high-dose Niacin (or extended-release Niaspan), have you experienced acid reflux as a side effect? I was recently diagnosed with "reflux laryngitis" after complaining of throat swelling and hoarseness throughout the day, and when the ENT scoped my throat she saw a ton of...

I've read elevated prolactin in men can cause ED and other sexual dysfunction based on its inhibitory effects on the HPTA; however, I am curious to know if fluctuations in prolactin itself can cause ED in a TRT patient? I have a documented pituitary adenoma that has seemed non-functional for...

I'm on a successful TRT/AI/HCG protocol with Defy and have been for some time. I generally feel good mentally and can typically perform sexually when necessary, but am just...blah...don't really care and don't have any real desire. One complicating factor is I am very low SHBG (10-15), so my...

I am a happy Defy patient on a stable daily TRT + HCG + AI protocol. I'm sure Dr. Saya will translate these results during our consult, but it's not for another few weeks, so I wanted to educate myself as much as possible as I am concerned. My cholesterol numbers have always been marginal. HDL...

I had a regularly scheduled blood draw with my PCP earlier this week. I am always on the lookout for elevated hematocrit being on TRT. This time around, my hemoglobin was slightly elevated, but hematocrit was normal. Is this diagnostically significant? Hemoglobin: 17.8 (13.0-17.0) Hematocrit...

I've been on TRT since March or so. Protocol is stable shooting 20mg T + 150iu HCG ED, 0.125mg anastrozole EOD. For the past couple of months I have been struggling with water retention, about 8 lbs or so extra than normal. It is manifesting mostly in my neck and face although my pants feel a...

I'm going to give Defy a call tomorrow but in the meantime just wanted to educate myself a bit on this topic with your help. I started TRT a few months ago after an unsuccessful clomid run. My latest labs are in great shape and I'm feeling great. Reasonable trough T at 700-800, E2 at 35. But...

I inject 80mg T twice a week. Until recently I would draw T with a large needle, then using LL would replace the large needle with 1/2" to inject T SubQ. The issue is every shot hurts like hell and bleeds afterward. So a few days ago I drew the T but then back filled it into one of my 31 gauge...

I have searched a bit around here and other places and have found quite a few suggestions, but thought I would ask specifically on my circumstance to see if anyone has any thoughts. On TRT+HCG+AI with the following regimen: Mon & Thurs 100mg T (total of 200mg/wk) 500iu HCG (total of 1,000...

I have been on clomid 12.5 E3D for several months now with great success, Total T in the upper 900s. The one issue is the E2, which when tested with the sensitive test, comes in in the upper 80s, despite increasing doses of Arimidex, now up to 0.25mg twice a week, pending another assessment next...

Although it took literally over a month to begin to "feel" the subjective results, I am now doing really well on Clomid. I've stepped down from 25 ED to 12.5 ED to 12.5 EOD, but my LH/FSH and E2 are still through the roof. Weirdly, the LH/FSH response has trended higher as I have stepped down on...

New doc wants to try clomid to replace old doc's HCG mono protocol that was beginning to lose its effects despite increased dosage (perhaps downregulation). I am almost two weeks in with the following (stopped HCG cold turkey): 25mg clomid ED 0.125mg Arimidex + 200mg DIM (compounded together)...