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Question for those using daily injections of testosterone cypionate: I know there’s going to be very little variation in blood levels on a daily injection protocol. I’m curious though about the peak on a daily protocol. Would it be 12 hours post injection? If so, I could possibly see a small...

Anyone using testosterone cream daily applied to the scrotum as their primary delivery method for TRT? Can you share some details such as dosage amount and how you are feeling including mood, libido, and energy? Also, are there any negative sides you are experiencing? Thanks

Once weekly, twice weekly, and daily injection protocols....Which of these injection schedules do you think yields the highest DHT levels? Thanks

SHBG is talked about a lot as a good predictor of how fast one clears testosterone out of their body. Low SHBG frequently necessitates the need for more frequent injections per week. Do factors such as EGFR and hypothyroidism also factor into how fast an individual processes testosterone? On the...

I know this is going against the grain a bit, but I’m curious. Is there anyone out there who has tried both once weekly injections as well as multiple smaller injections per week and felt better on once weekly injections? If you have tried both and like once weekly better, can you explain why...

For those that are also on thyroid medication, can you describe your journey in getting your thyroid levels optimized including type of medication, dosage, pitfalls or mistakes you made along the way, and the noticeable positive impact thyroid meds have had on your life? Thanks

For someone not on TRT, does pregnenolone supplementation have any effect on the HPA axis? I’ve been off of TRT for over 6 months and was thinking about trying low dose pregnenolone(10 mg once or twice daily). I’m curious if anyone has any insight on whether pregnenolone would have any effect on...

I have been taking creatine for a few months now. I recently got back some labs that are a little concerning. GFR: 48.9 (>60.0) Creatinine: 1.6 (0.7-1.3) My past GFR’s have normally ranged between 70-90. Should I stop taking the creatine? Thanks

This question is for the guys who backfill syringes. How many do you normally backfill at one time? Do you think there’s any concern with the testosterone oil interacting with or eating away at the rubber stopper? Thanks

I know many times testosterone is not the only hormone we are deficient in. For those of you with thyroid issues, is anyone taking a specifically compounded T4/T3 thyroid med other than NDT? I’ve noticed Empower Pharmacy offers specifically compounded ratios of T4/T3. I’m currently taking...

Do more frequent injections lead to lower DHT blood levels?

Empower Pharmacy has a new 160/40 cyp/prop blend. Is anyone using this form of testosterone blend? If you are, how do you feel? Also, is anyone else using just propionate? I’d be interested to see anyone’s experiences using either of these formulations. Thanks

I’m curious as to how TRT affects lipid values. Has anyone had any experience with HDL and LDL values being affected positively or negatively after being on TRT for a while? Thanks

Anyone else experience cold hands/feet and brain fog the first few hours post injection? I’ve always experienced this phenomenon no matter what dose I’m injecting. I’m currently injecting 14mg shallow IM daily and taking 2 grains of natural desiccated thyroid. Who knows why. I’m just curious if...

Backfilling Insulin Syringe Question... For those of you that are backfilling syringes and injecting testosterone daily, how do you store the syringes after backfilling them? Is it ok to lay them down flat? Is there a concern of the oil leaking out? Any other tips about how to backfill would be...

This goes out to the few and the proud that chose topical creams or gels over injections. What lead to your decision to choose creams/gels over injections? Can you be specific as to the factors such as mood, libido, blood work, energy, estrogen management, more stable blood levels that might...

Has anyone ever experienced thinning hair while taking any form of natural desiccated thyroid such as Naturethroid? I have tried it at doses of half grain to 1 grain a day, and within the first few days, I notice noticeable hair thinning in the front of my hairline. My labs show I need thyroid...

What injection sites do you rotate? Do you inject subq or IM? What size syringe do you use? Do you backfill or not? Do you use HCG? Finally, what’s your daily dose? Thanks, I’m thinking about giving daily injections a try.

For those with experience, do subq injections decrease estrogen levels? I’ve done a little research and found varying opinions on this. Thanks

Does grapefruit lower hematocrit? If so, is the whole fruit better or the juice?

I started TRT recently with Defy. My starting protocol is 40mg of testosterone and 200iu of HCG 3 times per week. I recently had my 6 week follow up labs done. The first lab I got back was the CBC. Here is what I’m concerned about: Hematocrit increased from 45.2 to 50.0 MCV increased from 99.0...

I just bought a product by Life Extension called Cognitex With Pregnenolone. I added this as an adjunct to my TRT. I have had several concussions/TBI's in my past. I thought it might be a little insurance against future brain disease. It has pregnenolone in it which has been proven to decline in...

I just finished my first full week of my new protocol set by Dr Saya and Defy. My starting protocol is 40mg of test and 200iu of HCG injected on MWF mornings for a total of 120mg of test and 600iu of HCG weekly. Everything is going fine so far except for one thing. I'm injecting subq with a 29G...

HCG reconstitution question... So today was the first time I've ever reconstituted HCG. I forgot to draw out air from the HCG powder vial before I added the water to it. It was very hard to press all of the water in the vial because of the pressure. When I drew out the mixed HCG for my first...

New Protocol Advice... I'm a new patient with Defy. Dr. Saya is my doctor. The protocol he is starting me out on is 40mg of test cyp and 200iu's of HCG injected 3 times per week for a total of 120mg of test cyp and 600iu's of HCG weekly. My SHBG was is fairly low at 24 which is why he is...

My DHEA levels are always at the top end of the normal range. Is this a good indication that my pregnenolone levels are good? I'm curious if there is a positive correlation between DHEA and pregnenolone. Thanks

Has anyone ever read anything about mold exposure lowering testosterone and even accelerating the conversion of testosterone to estrogen? Thanks, I've read a little about this topic and was interested in learning more.

Has anyone noticed increased sun sensitivity while taking HCG? Have you noticed that you burn faster or easier? Thanks

I had my first initial consult with Dr Justin Saya this morning. To say I was impressed and literally blown away would be an understatement. He is by far the most knowledgeable and impressive doctor I have ever worked with concerning TRT. He is an incredible listener as well. I'm fairly young at...

I have my first initial consult with Dr Saya this coming Tuesday. For any Defy patients on the board, do you have any advice or suggestions? Looking back on your journey with Defy, would you recommend any info or questions to have ready for the appointment? Thanks so much for the info!