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    Less estradiol with faster-acting testosterone?

    Just putting this out for discussion and comments. There have long been anecdotal suggestions that faster-acting testosterone leads to lower overall levels of estradiol. In particular, it's often claimed in regard to using testosterone propionate versus longer esters such as cypionate. It could...
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    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    Lately I’ve been insinuating that some testosterone suspension products may qualify as fast-acting, and therefore be in the same league as testosterone nasal gels and buccal troches. The “fast-acting” quality is important if the goal is to retain HPTA function in the presence of exogenous...
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    What affects free testosterone under TRT?

    I’ve covered this issue in many posts, but I thought it would be helpful to put more information in one thread and expand on the topic. TL;DR: Under TRT, free testosterone is proportional to the dose rate and inversely proportional to the metabolic clearance rate. The liver accounts for most of...
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    High testosterone is like … finasteride? Say what!

    It’s not quite as off-the-wall as it sounds. We know that as serum testosterone increases the 5α-reductase enzyme starts to saturate, leading to a reduced efficiency in DHT creation, illustrated thusly: Even so, with high testosterone a lack of DHT is not going to be a problem; there’s still...
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    A treatment candidate to reduce HPTA suppression under TRT. Possible hCG alternative?

    TL;DR: Some research suggests that echinacoside may complement a SERM in reducing TRT-induced negative HPT-axis feedback at the hypothalamus. Background: In testosterone replacement therapy, elevated levels of testosterone and estradiol apply negative feedback to the hypothalamus. This...
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    A different dosing strategy with bremelanotide (PT-141) yields dramatically better results

    TL;DR: It may be possible to improve results with bremelanotide by taking multiple daily micro-doses. Like many, I have experimented with bremelanotide at the recommended doses, which range from a few hundred micrograms up to a couple milligrams in one subcutaneous injection. And also like...
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    Imbalance of testosterone/estradiol promotes male CHD development

    I recently came across this article. It's not new, but the search function doesn't turn up previous discussions about it on ExcelMale. Imbalance of testosterone/estradiol promotes male CHD development Hong-Yun Zheng 1, Yan Li, Wen Dai, Chuan-Dong Wei, Kai-Sheng Sun, Yong-Qing Tong Abstract...
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    RF9: May it be a new therapeutic option for hypogonadotropic hypogonadism?

    Intriguing stuff, possibly highlighting another distinct cause of hypogonadism, along with a new treatment option. There's been little discussion of gonadotropin-inhibitory hormone or GnIH. This hormone counters kisspeptin and suppresses the HPTA. An excess of GnIH may lead to hypogonadism. RF9...
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    Brain estrogen creation 'critical to maintain full sexual activity or desire in males'

    A tip of the hat to "PakMan" at PeakT for the reference to this article. The underlying work is on mice, but may have implications for humans. Summary: Researchers have uncovered specific regions of brain tissue where aromatase is present, that drives male sexual desire. Aromatase converts...
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    Kisspeptin suppression under TRT: Can it affect mood and libido?

    TD;LR: Kisspeptin may affect how we act and feel. It seems plausible that a TRT-induced reduction in this hormone is a problem for some men. I’d previously asked if suppression of GnRH by TRT is a problem. The literature at least hints that it is possible. The situation with kisspeptin may be...
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    Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene

    TL;DR: Over a period of seven weeks, treatment with GnRH and enclomiphene raised LH and FSH from around 0.1 mIU/mL to about 1.0 mIU/mL, even though TRT and hCG dosing were continued. Subjective results have been encouraging. I had written previously on the subject of GnRH suppression on TRT...
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    Is GnRH suppression hurting us?

    Admittedly the last thing we need is some other nebulous danger to worry about that may not even exist. Read on at your peril. TL;DR: Testosterone replacement therapy suppresses the production of GnRH. Receptors for GnRH are found in places besides the pituitary. One animal model suggests GnRH...
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    rT3 halved under liothyronine (T3), fT3 & fT4 lower, what next?

    Pre-treatment: TSH: 2.8 (0.45 - 4.5 uIU/mL) Free T3: 2.7 (2.0-4.4 pg/mL) Free T4: 1.4 (0.82-1.77 ng/dL) rT3: 23 (9.2-24.1 ng/dL) I was prescribed liothyronine and told to start with 5 mcg/day and titrate up to a maximum of 20 mcg. I tried the 5 mcg dose for a couple weeks, then went to 10 mcg...
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    Does SHBG affect the apparent half-lives of testosterone esters?

    The relative level of SHBG has a pronounced effect on serum levels of testosterone delivered via TRT. This is through the influence of SHBG on the metabolic clearance rate of testosterone. But as far as I can tell the effect on the apparent half-lives of testosterone esters is subtle at best. Is...
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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