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The abstract below is from a systematic review and meta-analysis concerning the impact of aromatase inhibitors (AIs) on male sexual desire. The study investigated whether these medications, sometimes used for male hypogonadism due to their effect on the hypothalamus-pituitary-testis axis...

Thanks to Dr Sun for this diagram. Timeline details (left → right) YearProduct (image above/below the line)Form & delivery 1935-1937No product image—text block below the line: “Testosterone first synthesized” with a bullet list of early preparations (oral 17α-methyltestosterone, injectable...

This scientific paper investigates the effects of smoking cessation on hormonal levels in men, specifically focusing on steroid hormones like testosterone, DHEA, DHEAS, cortisol, and sex hormone-binding globulin (SHBG). The researchers aimed to determine if these hormonal levels could predict...

Introduction Many common medications – both prescription and over-the-counter – can influence the muscle mass and strength gains achievable through resistance exercise. Some drugs impair or blunt muscle hypertrophy and strength development, while others enhance or exaggerate these gains. These...

These articles discuss how histamine-blocking drugs, often taken for allergies, can negatively impact the physiological benefits of exercise. Both sources present studies indicating that high doses of antihistamines interfere with muscle adaptation, blood flow increases, and overall fitness...

ExcelMale.com is widely regarded as the ultimate online forum for testosterone replacement therapy (TRT) and men’s health discussions. Founded in 2013 by a leading men’s health advocate, this platform has grown into a vast community with tens of thousands of members, ranging from newcomers...

From this thread: WARNING: Do not believe Internet "gurus" proclaiming no need to manage hematocrit on TRT - Excel Male TRT Forum Underlying Physiological Mechanisms Testosterone Replacement Therapy (TRT) and Erythrocytosis: Exogenous testosterone stimulates red blood cell (RBC) production...

Friends, over the years ExcelMale.com has grown into a knowledgeable, supportive community, and many of you have already taken the time to read my latest project, “Beyond Testosterone: The Illustrated Guide.” If the book has clarified a lab result, sparked a productive conversation with your...

Briefing Document: Estradiol in Men on TRT Source: Excerpts from "High Estradiol in Men on TRT: What to Do" by Nelson Viegel (excelmale.com) 1. The Role and Importance of Estradiol in Men Core Idea: Estradiol, often misconstrued as a solely "female hormone," is crucial for male health and is...

A new study published in Scientific Reports (Nature Publishing Group) has found a potential link between eating foods rich in live microbes—like those found in yogurt, kefir, kimchi, and other fermented foods—and higher testosterone levels in men1. Why Testosterone Matters Testosterone is a...

Sex hormones like estrogen and testosterone don’t just affect things like body shape or voice—they also play a role in how the immune system works. This is especially important for transgender people who take these hormones as part of their gender-affirming care. However, there’s not much...

Managing the Testosterone-to-Estradiol Ratio in Men on TRT Introduction Testosterone replacement therapy (TRT) in hypogonadal men often leads to an increase in estradiol (E2) levels due to the aromatization of testosterone. This alters the testosterone-to-estradiol (T:E) ratio, a metric...

Summary of Study Findings: "Reduced IGF-1 Levels Following Clomiphene Treatment for Male Hypogonadism" (Journal of the Endocrine Society, 2025) Objective: To investigate whether clomiphene citrate—a selective estrogen receptor modulator used off-label to treat male hypogonadism—affects serum...

Study article link: Does creatine cause hair loss? A 12-week randomized controlled trial - PMC Background and Purpose Creatine is a popular supplement known for enhancing muscle strength and lean mass. Despite its benefits, concerns have circulated that creatine may promote hair loss by...

Study at a Glance Title: “Assessing the Impact of GLP-1 Receptor Agonists on Sexual Desire: A Qualitative Review” Authors: H. Quaile & R. Horwitz Journal: Journal of Sexual Medicine — published 1 April 2025 Why This Matters Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) such as...

“Best” depends on what problem you’re solving, how often you want to inject, and what your pharmacy/insurer will actually supply. Below is a head-to-head snapshot followed by practical guidance. FeatureHydroxocobalaminCyanocobalaminMethylcobalamin Regulatory status (U S.)FDA-approved...

Vitamin D Status Shapes the Cardiometabolic Pay-Off of Testosterone Therapy in Late-Onset Hypogonadism Abstract Late-onset hypogonadism (LOH) is common in aging males and is frequently accompanied by features that drive cardiovascular and metabolic disease. Separately, vitamin D insufficiency...

Background: Please read this previous article: https://www.excelmale.com/threads/heart-palpitations-and-afib-in-older-men-on-testosterone-signals-from-traverse.28247/ New Data: https://www.sciencedirect.com/science/article/abs/pii/S0002870325001206 Neutrophil and Monocyte Changes in...

Everyone is talking about GLP-1s. As these so-called "miracle drugs" for weight loss exploded in popularity, shortages quickly followed. That’s when compounding pharmacies stepped in, offering lower-cost, customizable versions of these medications. But are patients really getting the same...

PSA Screening, Prostate Biopsies, and Prostatitis: Prevalence and Outcomes Frequency of PSA-Triggered Biopsies (U.S. and Global) Prostate-specific antigen (PSA) screening became widespread in the 1990s, resulting in a high volume of prostate biopsies. In the United States, approximately 1...

Uso de hCG Junto a la Terapia de Reemplazo de Testosterona Hola chicos, soy Nelson Vergel de ExcelMale.com. Hoy voy a explicar cómo usar hCG junto con la terapia de reemplazo de testosterona (TRT). Algunos hombres con testosterona baja necesitan esta terapia, ya sea a través de geles recetados...

Introduction to the Gut Microbiome The human gut microbiome—an intricate community of trillions of bacteria and other microorganisms—has become one of the most fascinating subjects in medical research. A recent systematic review sheds new light on its role, particularly highlighting its...

Has anyone tried this? One of my coaching clients had a 7 point drop in hematocrit. https://leviathan-nutrition.com/products/new-leviathan-hemo-flow-hematocrit-blood-viscosity FREQUENTLY ASKED QUESTIONS WHAT DOES HEMO FLOW DO? HEMO FLOW addresses the rampant issue of high hematocrit...

Extremely interesting podcast. I wonder what you guys think.

Examining One of the Top Online Men's Health Communities. Introduction Nelson Vergel started ExcelMale.com, which has grown to be—among men looking for advice on testosterone replacement treatment (TRT), hormone optimization, and associated medical concerns—one of the most reliable internet...

Great list of things you can use AI for (I use ChatGPT and Perplexity a lot for these and more ) https://www.artofmanliness.com/skills/manly-know-how/how-to-use-ai/

The FDA’s recent regulatory crackdown on tirzepatide compounding has far-reaching implications for both pharmacies and patients. Strict deadlines have been set for compounding pharmacies to stop producing tirzepatide, leaving many individuals concerned about affordable access and treatment...

Download the app here Home - Nanolume

Debunking the Myth About High Hematocrit in Men on TRT I know many of you want to feel reassured that managing hematocrit isn’t necessary. However, misinformation is spreading, with some "bro science" videos and even a few so-called expert doctors claiming that men on TRT don’t need to worry...

Tirzepatide Dosing for Weight Loss: A Guide Tirzepatide is a big deal in weight management pharmacology. As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide has worked amazingly well in clinical trials for weight loss...

https://bmjoncology.bmj.com/content/4/1/e000520 The main findings of the study on prostate cancer risk in men with testosterone deficiency (TD) and a family history of prostate cancer (PCa) receiving testosterone therapy (TTh) are: - **Prostate Cancer Risk:** There was no significant...