GLP-1 Medications Effects on Testosterone, Free Testosterone, SHBG, and Estradiol

[Nelson Vergel]

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GLP-1 Medications and Men's Hormones: Effects on Testosterone, Free Testosterone, SHBG, and Estradiol

Effects Beyond Weight Loss

excelmale.substack.com

 

[Nelson Vergel]

Thread 'GLP-1 Medications: Preventing Muscle Loss During Treatment & Weight Regain After Discontinuation'

Jan 25, 2026

GLP-1 Therapy Clinical Guide
Preventing Muscle Loss During Treatment & Weight Regain After Discontinuation
Evidence-Based Strategies with Annotated References​

Executive Summary​

GLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide) have revolutionized obesity treatment, producing weight losses of 15-25%. However, two critical challenges require proactive management: preserving lean muscle mass during treatment and preventing weight regain after discontinuation. This guide synthesizes current evidence and provides actionable clinical...

• Nelson Vergel
• preventing muscle loss glp-1 semaglutide tirzepatide weight regain after glp-1
• Replies: 4
• Forum: Weight Loss Options

 

[Nelson Vergel]

Thread 'Testosterone Levels Improve in Men under GLP-1 Receptor Agonist Therapy'

May 13, 2026

Dr. Andres Guillen Lozoya discusses findings from, "Testosterone Levels Improve in Men under GLP-1 Receptor Agonist Therapy.” This study aimed to evaluate changes in total and free testosterone before and after GLP-1RA therapy in men

• madman
• Obesity; Testosterone; Glp-1; Health
• Replies: 0
• Forum: Testosterone and Men's Health Articles