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It wears off slowly over a period of hours. The erections last longer with higher dosages, and it lasts longer with tri-mix versus bi-mix. Yes, you could use viagra after it has worn off. I would be careful not to take any viagra while the injection was still working strongly though. What...

1. Possible with reckless use of tri-mix. Very unlikely with careful use of tri-mix. Virtually impossible with bi-mix. 2. Very rare. It seems to require a combination of injecting the same exact spot over and over again, not allowing it any chance to heal, while causing significant tissue...

% body fat, fasting glucose, fasting insulin, HbA1c, HDL, triglycerides? Keto diet, wean off psych drugs.

Make sure you get labs on this before making a change.

Welcome! Awesome. What did you learn?

No guarantees, but it's certainly worth the experiment! There may be hope for you yet.

I had totally forgotten about this thread. So, you had already received some strong testimonials here, which should have prompted experimentation with different injection methods seven months ago, and ignored it completely. Doesn't bode well for your chances of dialing in on TRT.

Most likely dropping the AI is responsible for increased libido, more than ED injections. Aromatase inhibition in the brain is a well known libido killer.

If 35 mg weekly feels like too much, take that as strong evidence that something is wrong at a fundamental level, either with you, what you're taking, or how you're taking it. Insanity is doing the same thing over and over again while expecting different results. This race to the bottom...

Stick the needles into your delts and ventroglutes and depress the plunger. Run labs again in 6 weeks. Try to refrain from starting new threads in the meantime.

I would try reducing dose first, then try adding hCG, then return to injections if those two fail. You could try a hybrid protocol in that case with a base of injections and a small amount of cream on top for the libido boost.

You're right on this point, always a good thing to explain to noobs. I took it for granted that he understood this. Yes, we know you well. Besides stern, I would include some other adjectives: belligerent, abrasive, scornful. But well-meaning, with occasional hints of warmth and humanity. I...

Even if it is, I still feel like this is a red herring in terms of your TRT difficulties to date. Don't take my word for it though. Try something that significantly increases your DHT level at some point and observe the effects. There are many options available now: topical testosterone, oral...

That's fair, and I did not say, nor would I ever say, that injecting subq is certain or even likely to lead to higher E2 vs IM. I said it's very common, and I'll define common the way they do for side effects of prescription medications: incidence rate greater than 10%. Based on what I've seen...

6+ weeks Probably not, remember your SHBG is extremely low, and your free DHT is likely very good. You can always experiment with scrotal cream at some point if you want to see what supraphysiologic DHT feels like.

I wouldn't start with bigger injections, I would start with IM as your first experiment. If you need some inspiration, just go to reddit, and look at how many people feel like hot garbage on SC.

Higher E2 with SC than with IM is a very common finding in the real world. It's happened to many men on this very forum (including myself) and if you search on Reddit you will find many (many, many) more examples. When this happens, how does it happen? My hypothesis: esterases needed to...

Awesome - odds that the algorithm I dropped for you gets everything sorted are now excellent.

Every time a TRT noob watches this video, an angel gets its wings:

I missed this earlier. Are you obese? Are you insulin resistant? What does your lipid panel (HDL and Triglycerides), fasting glucose, HbA1c, fasting insulin look like? E2 at 47 means sky high free E2 with single digit SHBG. You may have some work to do on metabolic health before you will...

I recall you were injecting subq - have you switched to IM yet? Must try if that hasn't been done yet. Otherwise, I would try another formula of injectable T, and if that fails another modality. It seems like your current formula is going to make you feel like shit every time you inject it, so...

Have you guys seen this? https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/empower-clinic-services-llc-dba-empower-pharma-700962-04022025 Not a good look!

Absolutely, yes. The idea that SHBG predicts what injection frequency will be optimal for you is an old wives' tale.

It's a reasonable thing to try, among many other reasonable things to try (different esters/formulas, different injection methods/sites/depths, other forms of TRT like topical and oral). You would like accurate predictions about how you will respond to these various interventions, to save...

There isn't enough emphasis on the fact that weird and unpleasant symptoms are quite possible when starting TRT, which are likely temporary, and shouldn't be interpreted to mean you cannot tolerate TRT generally or even the particular form you're using. I'm certain I also reached a bunch of...

UGL

We suggest once per day dosing because it is simple and effective for the majority of patients. Some 10% of patients seem to prefer twice daily dosing, so it can be worth experimenting with. It may seem counterintuitive, but there is often no strong relationship between your serum level of...

No, it's not possible that injections will fail to raise her levels. If you inject subq, maybe a percentage is lost to the void like sometimes happens with test, but in that case you just inject more. The levels will come up. 1.2 mg estradiol cypionate EOD, 299 pg/ml total E2, 3.56 pg/ml free...

Cypionate or enanthate. We started with E3.5D but had better results with EOD cypionate.

For many women, estradiol doesn't help until you reach 200+ pg/ml - lesser administration methods and mainstream docs will rarely get you there. Beware of elevated SHBG, which increases the total E2 they need to feel good, just like testosterone.

There's always a way. https://hrtcafe.net/Estrogen/estradiol_injections.html