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Defy Medical TRT clinic doctor
  1. FunkOdyssey

    I started with oral TRT with Maximus last week. I have a couple of questions....

    I work for Maximus and can answer some of these questions for you. 90% of patients stick with a single morning dose. 10% prefer to split the dose, and take some amount of it a bit later in the afternoon. If you're curious to try splitting the dose, reach out to your Maximus provider and...
  2. FunkOdyssey

    Brain health with trt, missed sleep

    I don't think there's any way to predict what levels will produce optimal cognitive function for a given individual. I would suggest experimenting with different levels and see how you feel. Once you are aware that testosterone can affect cognition and are looking for that effect, I think it...
  3. FunkOdyssey

    Brain health with trt, missed sleep

    Yes. There's some real neuroscience underpinning the meathead gym bro stereotype.
  4. FunkOdyssey

    Brain health with trt, missed sleep

    I have to give @madman credit for posting the inverted U cognition study. The effects of testosterone increasing dopamine in the limbic system are more well known, so I don't remember where I came by that. You can just ask chatGPT about it for more info and studies.
  5. FunkOdyssey

    Brain health with trt, missed sleep

    Same assumptions here, it is very counterintuitive. In the limbic system you have the exact opposite situation, where testosterone is increasing dopamine levels and reward circuit activation. You can start to imagine how these opposing forces play out with rising testosterone, making you more...
  6. FunkOdyssey

    ED/low libido even with TRT

    Thanks for noticing. It does seem like a huge blind spot in the community and among providers. They understand the free hormone hypothesis as it applies to testosterone, and then for some reason fail to apply the same concepts to estradiol. As with T, free E2 is all that matters, and you need...
  7. FunkOdyssey

    Impact of TRT and Supraphysiological Testosterone Doses on Biological Aging

    You're thinking of the infamous Dr. Keith Nichols.
  8. FunkOdyssey

    Brain health with trt, missed sleep

    There's some similarity in the effect on energy and mood (both increase with increasing testosterone serum levels, up to a point), but not focus / executive function, which as mentioned elsewhere is only optimized by the mid-range levels of an inverted U before it declines with increasing...
  9. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    Depending on the dosage (let's assume at least 100 mg daily) and the individual, it could land anywhere between 150 - 500 ng/dL, occasionally even higher. Mine was in the mid 300s on 150 mg daily.
  10. FunkOdyssey

    ED/low libido even with TRT

    Yes, he needs to retest with SHBG. That E2 of 47, in a low SHBG context, could certainly be high enough to cause ED and loss of libido in some men. Then he'd be looking at dose reductions to sort that out, preferably starting with reducing or eliminating hCG as a first experimental step.
  11. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    There's more to pharmacokinetics than ester. Release from the oil depot is accelerated by low viscosity MCT oil and small depot size relative to testosterone injections. If you don't mind the swings or don't perceive any swings, inject as infrequently as you like.
  12. FunkOdyssey

    Any Testosterone Propionate Compounding Pharmacies left?

    Time to apologize to twohunglow. Domestic suppliers are starting to run out of basic testosterone products like testosterone cyp and enanthate. The sky is actually falling as a result of the raws shortage.
  13. FunkOdyssey

    Testing out Proviron for Libido

    It works, I just can't tolerate it, because it does what elevated DHT always does to me: flares up my usual mild GERD symptoms to a severe and debilitating level. So, there's definitely DHT in there.
  14. FunkOdyssey

    T Propionate protocol

    Individuals send him unlabeled samples to verify potency from different suppliers.
  15. FunkOdyssey

    T Propionate protocol

    I would only do big pharma testosterone or UGL at this point. I feel like compounded testosterone is essentially the same thing as UGL, except more expensive, and with less assurance of potency because no one sends it to Janoshik.
  16. FunkOdyssey

    T Propionate protocol

    Honeymoons are common with almost any change in protocol. With this change specifically, the first couple of weeks you had higher levels due to adding prop on top of lingering long ester, contributing to a possible honeymoon, and you also had lingering long ester keeping your troughs higher...
  17. FunkOdyssey

    Brain health with trt, missed sleep

    Regular prop in grapeseed oil.
  18. FunkOdyssey

    What affects free testosterone under TRT?

    LOL, this new AI version of Vince will take some getting used to.
  19. FunkOdyssey

    Brain health with trt, missed sleep

    Euphoric when they first kick in, and ability to concentrate is enhanced for several hours. Strong dysphoria develops during the evening crash, with exaggerated ADHD symptoms (worse than baseline), and severely impaired ability to sleep. Heart rate and blood pressure are increased also. The...
  20. FunkOdyssey

    Brain health with trt, missed sleep

    Can't think clearly, can't maintain a train of thought or hold much information in mind for long (impaired working memory), planning anything is difficult, can't focus very well, frequently forget what I am doing at work when I switch between different parts of a task (working memory again). It...
  21. FunkOdyssey

    Brain health with trt, missed sleep

    Run labs at peak (~5-6 hours after injection) and trough. I think you will find your peak is obscenely high on this protocol. I find my cognitive function is absolute trash with a free T in the 40's ng/dL, and that's likely where you are, if not higher. I'm running 13 mg test prop daily right...
  22. FunkOdyssey

    TRT and health tracking (e.g. sleep) with smart ring (oura)

    You use the oura ring to identify relationships between the things you are doing in your life and your sleep, heart rate, HRV, etc. You see how things are currently, then something changes: you drink alcohol close to bedtime, you change your TRT dose, you stop drinking coffee, whatever it might...
  23. FunkOdyssey

    Thinking about TRT and could use some guidance

    Testosterone helps a little, very indirectly and inefficiently compared to a GLP-1. The degree of self-discipline required to get lean is not significantly reduced by testosterone - every obstacle to leanness that currently exists in your life will remain, looming large as ever. As badassblues...
  24. FunkOdyssey

    Thinking about TRT and could use some guidance

    I feel like this response was twice as effective as my longer reply, because you said "Stop the finasteride" twice, which is really the crux of the matter.
  25. FunkOdyssey

    Thoughts / Advice on bloodwork

    I'm going to assume what Cataceous said is correct, because I can't make out those lab numbers at all. I would be inclined to try P5P for mildly elevated prolactin before resorting to the big guns.
  26. FunkOdyssey

    Thinking about TRT and could use some guidance

    These are likely finasteride side effects. It doesn't sound like your workout regimen *should* be causing substantial gains in mass and strength given the limited intensity. Testosterone is not an effective fat loss agent. Building muscle, yes. Losing fat, no. This particular goal would be...
  27. FunkOdyssey

    On TRT: How to check the state of cardiovascular system & how to find heart specialist

    You should look for someone that has good reviews, and is not inclined to shove a plant-based diet and statins down your throat. I found a low-carb friendly doc that is also testosterone friendly from an anabolic doc video, just so happened to practice 20 minutes away from me: They're...
  28. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    The easy and legal way to get a ton of DHT is to apply testosterone cream to the scrotum. Pure DHT is just easier when you have a TRT protocol that is already dialed in with regard to E2 and you don't want the E2 to move.
  29. FunkOdyssey

    Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis

    I subscribe to Chris Palmer's "Brain Energy" theory of mental illness (mental illness is a metabolic disease): https://www.amazon.com/Brain-Energy-Revolutionary-Understanding-Health-ebook/dp/B09SKPDT36/ https://chatgpt.com/s/dr_68b8813a3264819183e79734de133b42
  30. FunkOdyssey

    What are typical nandrolone plus TRT protocols?

    I tried one injection of NPP one time and started feeling negative mental effects almost immediately. I'm in no hurry to ever try it again.
  31. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    I have only seen reliable, repeated evidence of reduced serum E2 levels with the use of oral testosterone. Scrotal cream, which often increases serum DHT to 300+ ng/dL, does not typically reduce serum E2 - instead, scrotal cream increases E2 proportionately to testosterone dose (like other...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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