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TOO MUCH T3 FROM NDT = JOINT PAIN?
Latest labs (last dose of 2.50 grains (162.50mg) NDT taken only about 6h prior to draw): TSH:1.23 ref range: 0.450-4.500uIU/mL FT3: 5.00 ref range: 2.0-4.4pg/mL FT4: 1.60 ref range: 0.82-1.77ng/dL Anyone notice that too much T3 from desiccated thyroid causes a flareup in joint pain? Is a 5.0...- mcs
- Thread
- dessicated thyroid free t3 thryoid ft3 dialing
- Replies: 19
- Forum: Thyroid, DHEA, Pregnenolone, Progesterone, etc
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Add Metformin to TRT
My 4-month trial of Metformin (1.5g) proved me right: For all the wonderful health and ligevity-enhancing benefits, I' experienced a 36% drop in total testosterone since starting which I knew about and several studies have shown. I was already low normal (high 400s) which was not optimal, now am...- mcs
- Post #31
- Forum: When TRT Is Not Enough (ED, Libido, & More)
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GH SECRETAGOGUE PEPTIDES & IGF-1
I am 99% certain my high normal (for my age of 62) of 258 is from eating a diet in which my protein is mostly all from non-plant sources (cultured dairy, eggs, lean meats, fish, poultry, whey) + supplements like DHEA + training. I prefer this type of protein over anything plant-based. This...- mcs
- Post #7
- Forum: General Peptide Use & Information
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GH SECRETAGOGUE PEPTIDES & IGF-1
Anyone have data showing that if one's natural IGF-1 level is high normal for one's age as in my case (see below), would GHRH/GHRP peptides be contraindicated since they raise IGF-1 over time? The concern is not as bad as with straight GH, but is still an issue for long-term (cancer, CV disease...- mcs
- Thread
- Replies: 6
- Forum: General Peptide Use & Information
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Upped dose of NDT and my TSH went up!
How is it possible that I can take a higher dose of NDT and do my labs at the same time as prior and come out with lower TSH and T3? Prior labs (NDT dose @ 2.00 grains - 130mg): TSH: 2.03 FT3: 3.70 FT4:1.40 Current labs: (NDT dose @ 2.25 grains - 146.25mg): TSH: 3.29 FT3: 3.5 FT4: 1.5 No...- mcs
- Thread
- hypothyodism ndt dose tsh hormone
- Replies: 1
- Forum: Thyroid, DHEA, Pregnenolone, Progesterone, etc
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METFORMIN - no change in glucose readings
Has anyone seen better glucose results with immediate release v extended release? I also wonder if my 1.5g ER-niacin could be suppressing the effects of metformin. Metformin and Niacin SR Interactions - Drugs.com- mcs
- Post #11
- Forum: Health & Wellness
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METFORMIN - no change in glucose readings
Even more effective than Semaglutide, a GIP/GLP-1 combo, the latest! How were you able to get a scrip? How long on it? Besides you "feeling" less glucose, has it actually reduced fasting glucose levels? Weight/fat loss? How's the nausea? Constipation from delayed emptying?- mcs
- Post #8
- Forum: Health & Wellness
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METFORMIN - no change in glucose readings
I'm in the same boat always having had high FBG. Even if I eat a protein snack at night, it just raises my glucose levels the next morning. It just hangs. Was hoping Met would suppress that. Only thing that suppresses it is moderate exercise like taking a walk or fasting for 15+ hours and...- mcs
- Post #6
- Forum: Health & Wellness
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METFORMIN - no change in glucose readings
I assume you're non-diabetic? How long have you been on it? Strange our glucose readings don't change. I still don't understand exactly the mechanism but I think it has something to do with glucose homeostasis in that diabetics have impaired beta cell function whereas non-diabetics do not -...- mcs
- Post #3
- Forum: Health & Wellness
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METFORMIN - no change in glucose readings
I've been on Metformin for a month now. I am not diabetic and am taking it for the anti-aging and cardiovascular benefits, etc. I eat the same diet (low carb). I have not seen any difference in my fasting or postprandial readings. Same issue with taking berberine (which I still take with...- mcs
- Thread
- glucose metformin
- Replies: 11
- Forum: Health & Wellness
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Has anyone tried Tirzepatide (Mounjaro) - supposedly more effective than Semaglutide
The new GLP-1 + GIP all-in-one, Mounjaro. More here.- mcs
- Thread
- Replies: 7
- Forum: General Peptide Use & Information
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EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS
Interesting mechanism. In my case, despite my low carb diet (<100g), I think my insulin sensitivity has gradually degraded with age as is normal. I take glucose disposal agents like cinammon, banaba leaf, berberine, etc. but have not noticed much difference. I'm looking into metformin and...- mcs
- Post #17
- Forum: Nutrition and Supplements
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EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS
That seems to be a paradoxical to what one would think: that fasting would keep the fasting glucose levels lower and a bedtime snack would make them higher. Can't figure that one out. I am just the opposite. If I snack, my readings will always be higher, especially with any form of carbs or even...- mcs
- Post #15
- Forum: Nutrition and Supplements
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M
FAT LOSS DIFFICULTY
Down 12 lbs now. Starting to see the bicep vein gives me hope that fat loss is possible. I still credit this with the slight increase in my desiccated thyroid dose (I believe I was under-dosed). May need to bump the dose a little more so TSH is @ <2.00 (it's around 2.5 now). That and more days...- mcs
- Post #50
- Forum: Nutrition and Supplements
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FAT LOSS DIFFICULTY
Update: I have lost approximately 10 pounds since starting this thread. Some of that of course has been fat as well. Strength has gone down maybe a tiny bit. Calorie restriction is difficult but a necessity at this point. The only other thing that I still need to work on is hormone optimization...- mcs
- Post #48
- Forum: Nutrition and Supplements
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Defy shipping costs
- mcs
- Post #9
- Forum: Resources and Suppliers
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Defy shipping costs
2 pharmacies in that example. Shipping costs should not be marked up, but whatever.- mcs
- Post #7
- Forum: Resources and Suppliers
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Defy shipping costs
$52 shipping for an order of $135 + $45 for hair products- mcs
- Post #5
- Forum: Resources and Suppliers
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Defy shipping costs
Has anyone been able to find an alternative supplier that doesn't overcharge for shipping? I realize they are not the actual pharmacy, but charging as much or more than the cost of the item itself is insane. That is on top of an already marked up full retail price item.- mcs
- Thread
- Replies: 10
- Forum: Resources and Suppliers
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EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS
I don't care how many credentials a cardiologist may have behind their name. If they are completely pro-pharmaceutical and don't consider the whole picture and outside factors such as hypothyroidism, insulin resistance, diet, lifestyle, and are against non-drug remedies like fish oil, niacin...- mcs
- Post #12
- Forum: Nutrition and Supplements
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M
EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS
Along with all the other drawbacks, statins could actually increase Lp(a). From what you've stated + your labs, I don't see any reason why you would need to be on any lipid management, especially when you're fortunate enough to have thyroid & glucose levels optimized without any intervention...- mcs
- Post #10
- Forum: Nutrition and Supplements
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M
EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS
What were your numbers before the ezetimibe? How long on it before these labs? Did it have any effect on your trigs, LDL-P and small LDL? Or no effect? How are you able to get a prescription for a PCSK9 inhibitor when it is specifically prescribed for FH? My HDL is low as well. My total and LDL...- mcs
- Post #8
- Forum: Nutrition and Supplements
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EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS
Perhaps your doc is basing his opinion on this study which I hadn't seen before: Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects- mcs
- Post #6
- Forum: Nutrition and Supplements
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EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS
Just curious, so what are you using now to help reduce your Lp(a) and for general lipid management and has it been effective?- mcs
- Post #5
- Forum: Nutrition and Supplements
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EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS
I don't know what specifically your cardiologist is basing that advice on. I had seen this older article before. It isn't even a case of 'correlation doesn't = causation'. All it really says is that niacin is supposedly ineffective in preventing mortality and says nothing about it causing any...- mcs
- Post #3
- Forum: Nutrition and Supplements
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EXTENDED-RELEASE NIACIN & GLUCOSE LEVELS
Anyone notice impact on fasting and post-prandial glucose levels and a1c from taking high-dose ER niacin to manage lipids? I was on 1.5g per day and increased to 2g per day and now I'm noticing glucose levels about 10 points higher. Wondering if this will subside over time. I know some are...- mcs
- Thread
- a1c glucose lipids niacin
- Replies: 19
- Forum: Nutrition and Supplements
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Semaglutide Forum: Game Changer for Weight Loss
I am told that Semaglutide should be combined with methylB12 to help mitigate the nausea associated with taking it alone. Some compounding pharmacies are doing just that.- mcs
- Post #30
- Forum: Weight Loss Options
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Semaglutide Forum: Game Changer for Weight Loss
Kills 2 birds with one stone: stubborn bodyfat + insulin resistance.- mcs
- Post #28
- Forum: Weight Loss Options
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FAT LOSS DIFFICULTY - PART II
I don't see what your problem is. In fact I'd like to have your problem. Putting on muscle and losing fat? That is the best that could happen as muscle is metabolically active in a positive way unlike fat which just causes more inflammation. What I need to do is recomp. If I gained weight but it...- mcs
- Post #17
- Forum: Nutrition and Supplements
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M
DESSICATED THYROID CONTINUES HAVING ZERO EFFECT ON TSH; ELEVATED FT3, NORMAL FT4
When I first started treating my hypothyroidism, it was over 10 years ago and I started with T3 monotherapy. It had little to no effect and did not make me feel better. Since then, I've tried every mono and combination therapy under the sun. I think I will just continue my journey titrating the...- mcs
- Post #38
- Forum: Thyroid, DHEA, Pregnenolone, Progesterone, etc
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