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Several studies have shown a positive association between depression and obesity; however the underlying mechanisms are not fully understood. It is not known if this association is driven by altered sex hormone levels in men due to increased BMI. A total of 3925 men (224460years) were...

Aging men's testosterone decline is largely due to the fact that older men sleep less well than younger men. At least that's the conclusion of researchers at the National University of Singapore who studied 531 Chinese men aged between 29 and 72. The researchers measured the amount of...

Testosterone may help protect men against asthma, according to a paper published Tuesday in Cell Reports. The scientists looked at a protein involved in lung inflammation and found that testosterone decreased its production, at least in mouse cells in the lab. Estrogen and progesterone didn't...

We still regularly have members join us who have been prescribed an injection of testosterone, 200mg, every two weeks. New to the TRT game the member, in all good-faith, wonders why he feels even worse than he did prior to the start of hormone therapy. We know that a protocol like this is a...

I'm quoting the abstract, but it seems a rather weak result. 1,410 men aged 20 + years who attended the morning examination session of the Third National Health and Nutrition Examination Survey (1988–1991) were included in the analysis. Coffee and soft drink consumption was...

In a small study at the Imperial College of London, 19 patients received a single dose of the psychedelic psilocybin. All had been diagnosed with, and were suffering from, depression that had been resistant to treatment. Twenty four hours after the ingestion of psilocybin, brain scans revealed...

At the present tine. flibanserin (Addyi, Valeant Pharmaceuticals) is the only approved therapy for hypoactive sexual desire disorder in women. However, it is only indicated for use in premenopausal women. According to Dr. Sheryl Kingsberg, hypoactive sexual desire disorder is the most...

Needle phobia is a well recognized phenomenon that it is believed affects 10% of the population. In the diabetic population, that number jumps to nearly 80%. Fear of needles is believed to be the single largest reason that many diabetics are not compliant in regard to maintaining an injected...

In a study that confirmed what seems so obvious to members of Excelmale, researchers have concluded that there is: "a lack of information on the prevalence of low testosterone in patients presenting with psychiatric complaints despite an overlap in clinical symptoms. The identification of...

Although two of seven studies showed reduced stroke risk, the review could not come to a definitive conclusion. Among eight RCTs, a low frequency of stroke events (<5) was observed across both testosterone and control groups, thus precluding any definitive conclusions. Based on these...

The news article says: Antares Pharma had applied for approval of the product for men with physician-determined hypogonadism. The prefilled, single-use injector enables patients to self-administer testosterone at home instead of applying a patch or gel, or having an intramuscular injection...

This news article on a talk at the American Association of Clinical Endocrinologists 2017 Conference surprised me Low adherence in men using testosterone gels Fewer than one in five hypogonadal men are adherent to prescribed topical testosterone, new research indicates. The findings, from...

It's well established that opiates, over time, can suppress male androgen levels, leading to hypogonadism. Danish researchers recently examined the question of non-prescription analgesics and the relationship they had to male reproductive function. Nearly 1500 men provided one semen...

Metformin, the first-line antihyperglycemic, has been touted as something of a wonder drug with strong, anti-aging properties. A recent study conducted in Toronto was undertaken to determine if Metformin administration had any impact on PSA levels. Over 300 men, all free of prostate cancer, were...

Another paper in the Asian Review of Andrology reviews the studies of cardiovascular events that were based on analyzing prescription records. Each study is summarized and its weaknesses discussed. The conclusion is that most studies have found no link between TRT and cardiovascular events. In...

New evidence suggests that fluoride may be an sexual hormone disruptor. From the abstract: We conducted a cross-sectional study in rural areas of Henan province in China to explore the interaction between the estrogen receptor alpha (ER&#945;) gene and fluoride exposure on reproductive...

It's been well established that waist circumference is a useful, reliable predictor for cardiovascular risk. However, until earlier this year it was not certain what its value was in regard to sexual health/quality of life status in hypogonadal men. Researchers enrolled 261 patients...

While there have been studies of the role TRT may play in terms of cardiovascular disease, there have been few focusing specifically on TRT and stroke. Testosterone Replacement Therapy and the Risk of Stroke in Men: A Systematic Review, "Maturitas, The European Menopause Journal." December 2017...

Does adding the measurement of cystatin C to that of serum creatinine to determine estimated glomerular filtration rate improve its accuracy? That's the question asked by researchers who undertook a meta-analysis of 11 general population studies (90,750 participants) and five studies of cohorts...

A recent study published in Diabetologiainvestigated the impact of DHEA, DHEAS, androstenedione, and the ratio of DHEAS to DHEA on type II diabetes. Data from 5,189 men and women were gathered. After adjusting for age, sex, cohort, fasting status, fasting glucose, insulin, and BMI, "both...

Another study showing TRT reduces the risk of heart disease. Full text of the journal article is available. Atrial fibrillation (AF) is the most common cardiac dysrhythmia associated with significant morbidity and mortality. Several small studies have reported that low serum total testosterone...

Reason Magazine has an article on steroid use in America, called How Washington Lost the War on Muscle. It also covers testosterone replacement therapy at length, with quotes from Dr. Morgentaler. Since it's a libertarian magazine, their position is we'd all be better off if steroids were legal...

This review (full text) discusses the studies and meta-analyses of adverse cardiovascular events from testosterone replacement therapy. Their conclusion is that no firm conclusion can be gathered from the studies to date. In summary, the number of cardiovascular events reported in TTrials...

Another paper in the Asian Review of Andrology reviews the studies of cardiovascular events that were based on analyzing prescription records. Each study is summarized and its weaknesses discussed. The conclusion is that most studies have found no link between TRT and cardiovascular events...

I keep reading posts that say DHT isn't the cause of BPH, estrogen is the cause. if thats the case then why do drugs like finasteride which lower dht actually shrink the prostate? if it was estrogen then taking finasteride would never shrink the prostate. Anyone have info?

A recent study failed to find a link between testosterone levels and male pattern baldness: A cross-sectional population study conducted in Northeastern Germany examined 373 men from the general population who had not received prescribed drugs in the past 7 days. Blood sampled were...

Testosterone therapy reduced pain and decreased opioid use in participants in this study. Over 18 months period, patients with Opioid Induced Hypogonadism (OIH) were identified in a tertiary referral pain center at the University of California San Diego (UCSD), Numerical Rating Scale...

This news article on a talk at the American Association of Clinical Endocrinologists 2017 Conference surprised me. Fewer than one in five hypogonadal men are adherent to prescribed topical testosterone, new research indicates. The findings, from a large commercial insurance database, were...

From the recent conference of the American Urological Association: The study focused on 200 men in a cardiology practice who completed the IIEF-15, ADAM, and previous ED treatment questionnaires. Additionally all patients had serum total testosterone (T), estradiol (E), and sex hormone...

Another retrospective study, presented at the American Association for Clinical Endocrinologists 2017 conference, shows the heart protective effects of TRT on men with secondary hypogonadism Testosterone replacement therapy (TRT) may exhibit a protective effect against myocardial...

Another study showing TRT reduces the risk of heart disease. Full text of the journal article is available. Atrial fibrillation (AF) is the most common cardiac dysrhythmia associated with significant morbidity and mortality. Several small studies have reported that low serum total...