Another paper in the Asian Review of Andrology reviews the studies of cardiovascular events that were based on analyzing prescription records. Each study is summarized and its weaknesses discussed. The conclusion is that most studies have found no link between TRT and cardiovascular events.
In large database studies that included over 215 000 T-treated men, most studies did not find that T treatment was associated with increased risks for mortality or for MI, stroke, or thrombosis. However, given the limitations of observational data, the cardiovascular risks of T treatment will remain unclear until a large, prospective, randomized, double-blind, placebo-controlled trial is conducted that is specifically designed to examine the risk for CV events with T treatment. Until then, clinicians should follow established clinical guidelines for T replacement and review potential risks of treatment with patients, recognizing that risks might be greatest in the first several months after initiation of testosterone therapy.
Full text of the article is online.
In large database studies that included over 215 000 T-treated men, most studies did not find that T treatment was associated with increased risks for mortality or for MI, stroke, or thrombosis. However, given the limitations of observational data, the cardiovascular risks of T treatment will remain unclear until a large, prospective, randomized, double-blind, placebo-controlled trial is conducted that is specifically designed to examine the risk for CV events with T treatment. Until then, clinicians should follow established clinical guidelines for T replacement and review potential risks of treatment with patients, recognizing that risks might be greatest in the first several months after initiation of testosterone therapy.
Full text of the article is online.
