Switched from Testosterone troche to SQ shots, feel horrible now.

Tylurnt · Jun 29, 2025

Been on anywhere from 25-50mg troche for 7 months now and after doing research found out it wasn't actually raising my levels. Only was for a short period after taking it, and when it wore off my levels would plummet. Was a 124 test morning before I took the troche. (Was 320 before i ever got on the troches)

Decided to switch to Test C subq shots. Took 50mg in the belly Friday (now its sunday) and have been feeling increasingly worse ever since. My symptoms are extreme fatigue/lethargy , heart palpitations, anxiety and very blah and low mood. Just feel out of it. Trying to figure out what's going on. Do you think I'm suffering from too little testosterone or too much?

Systemlord · Jun 29, 2025

I’ve been on injections and just about every protocol you can imagine and the worst protocol was sub Q. It sounds like your response is a little too robust. You might also be on too high a dosage.

I would recommend lowering your dose to around 40 mg IM twice a week and don’t be afraid to lower your dose even more, sometimes less is more.

You should wait a minimum of 4-6 weeks before drawing labs on new protocols.

If you haven’t already, I would recommend testing ferritin and iron saturation. Any deficiencies can be exacerbated on TRT, especially low ferritin and this can cause severe anxiety and fatigue.

An iron panel should be standard procedure prior to starting TRT.

FunkOdyssey · Jun 29, 2025

Friends don't let friends start with subq.

https://www.amazon.com/dp/B0CXF7V7BV

5/8" into the delt, ventroglute or quad. Lower dose isn't a bad idea either if your initial reaction is so unpleasant.

Tylurnt · Jun 30, 2025

Systemlord said:
I’ve been on injections and just about every protocol you can imagine and the worst protocol was sub Q. It sounds like your response is a little too robust. You might also be on too high a dosage.

I would recommend lowering your dose to around 40 mg IM twice a week and don’t be afraid to lower your dose even more, sometimes less is more.

You should wait a minimum of 4-6 weeks before drawing labs on new protocols.

If you haven’t already, I would recommend testing ferritin and iron saturation. Any deficiencies can be exacerbated on TRT, especially low ferritin and this can cause severe anxiety and fatigue.

An iron panel should be standard procedure prior to starting TRT.

What was bad about the subq protocol for you?

Jerajera · Jun 30, 2025

subQ was a terrible experience for me as well and I doubt it was placebo because I went into it very optimistic and expecting great results.

When running labs, TT and FT came back much lower than on the otherwise same IM daily injection protocol, and E2 much higher. This was 8 weeks after having switched from IM to subQ.

I can't explain it and I'm not sure what would cause that to happen, but that was my experience.

FunkOdyssey · Jun 30, 2025

Jerajera said:
When running labs, TT and FT came back much lower than on the otherwise same IM daily injection protocol, and E2 much higher.

Same here

Systemlord · Jul 1, 2025

Tylurnt said:
What was bad about the subq protocol for you?

Try to imagine being in a drunken stupor only that doesn’t come close. Some have called it an inflammatory response. I think it’s much more than that. I would compare to marijuana use, the way the brain is fogged up.

Amplify that 100 times, throw in some drugs and high percentage alcohol.