HCG Increases Pregnenolone?

jth0524

Member
Has anyone on here ever shown an increase in pregnenolone levels from taking HCG? Have you drawn labs before and after HCG use, and have the labs shown an increase in pregnenolone levels? My endo said the small HCG dosages like 500-1000iu's a week are not enough to make the testicles work like they were before starting trt. He said there's a big difference in using HCG in small amounts to prevent atrophy, and the much larger dosages used to increase fertility. I'd be interested if anyone has ever shown a marked increase in pregnenolone levels because of the addition of HCG to a trt protocol. Thanks.
 
I've posed this question about HCG and pregnenolone on several forums and groups. It's interesting that while some say it increased their preg levels, others report that it made no difference. I guess this goes back to the fact that we are all unique in how meds affect us. Thanks for the replies.
 
When you say increase, do you mean increased from before TRT?

Or did you start off on TRT, check pregnenolone levels, add HCG then checked pregnenolone levels again and they're still the same?
I had no increase until I added 10mg of pregnenolone once daily. Since my last labs I have stopped using supplementing with it.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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