Anti–Estrogen effects of DHT

Vince

Super Moderator
One important function of DHT in the body that does not get much discussion is its antagonism of estrogen. I've heard this in the past but I'm not sure how true it is.
 
My E has been very high in the 50-70 range using TCream on my scrotum to promote conversion to DHT so I don't know how true that is. My high E could be Pregnenolone or DHEA related, which I'm investigating now.
 
I don't know exactly how it works. I have that on my list to study. However, I do know that DHT has the opposite effect of E2 in many realms, which seems to make sense since DHT is the ultimate male hormone and E2 is the ultimate female hormone.

For example, E2 raises HDL, DHT lowers it; E2 causes water retention, DHT slight diuretic effect, E2 promotes fat gain, DHT promotes fat lose; E2 is a vasodilator, DHT is a vasoconstrictor.

I would if this is the antagonistic effect.

However, they obviously don't have opposing effects on skin, hair, prostate, and harrasibility


One important function of DHT in the body that does not get much discussion is its antagonism of estrogen. I've heard this in the past but I'm not sure how true it is.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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