Dosage for women's testosterone ?

[Mark7]

My wife has recently started transdermal cream testosterone. She has her first follow up with the Doc next week. She is still awaiting results of yesterday's blood test. Guidelines I've read say the typical dose, via click applicator, is in a range of 0.5mg to 2.0mg. Her dose is 1.5mg.

I'd like to know what dose is being used by women, especially if there was a marked increase in libido as a result. I would welcome any reports from the guys here.

 

[Vince]

5 mg T cypionate per week, or 2.5 mg twice-weekly for more stable levels.

 

[FunkOdyssey]

Less testosterone was more, and estradiol was more effective for sexual function and libido in our case. Under normal physiologic conditions / hormone levels, estradiol is the primary driver of libido in female mammals of all stripes including humans.

Testosterone plays more of a complimentary role at physiologic levels, except at very high supraphysiologic levels where a couple studies indicate it can increase sexual activity. I theorize that you are activating the male sexuality program when you go this high, as libido becomes more visual and male-like, versus normal female sexuality which is less pursuit-oriented and characterized by receptivity to male advances. There is some confounding by the fact that very high testosterone can contribute meaningfully to estradiol levels via aromatization.

Going too high (15+ mg weekly) in our case actually backfired and blocked the beneficial effects of estradiol. ~10 mg weekly as 1.5 mg testosterone propionate daily has been our best protocol for testosterone, only in combination with estradiol cypionate injections though.

There is some antagonism between androgens and estradiol at the tissue level that I think manifested as less lubrication and comfort during intercourse at higher test doses. One of many reasons to keep the T/E2 ratio closer to physiologic, others include maintaining normal female fat distribution, avoiding development of male-like personality characteristics, loss of female nurturing and empathetic impulses, etc.

 

[t_spacemonkey]

i've been experimenting on my wife with TRT, here is what I found:
- creams do absolutely nothing to raise her libido. and also do not show much on blood work, i think its mostly a scam
- injections, test enanthate: anything above 12mg/week = deep cystic acne within weeks, raging libido
- , injections, currently settled on 2x4mg/week, sweet spot of no acne and good libido

 

[FangFang]

i've been experimenting on my wife with TRT, here is what I found:
- creams do absolutely nothing to raise her libido. and also do not show much on blood work, i think its mostly a scam
- injections, test enanthate: anything above 12mg/week = deep cystic acne within weeks, raging libido
- , injections, currently settled on 2x4mg/week, sweet spot of no acne and good libido

I give my wife .02-03ml of 200 test injection twice per week. For her it's just the right mix. A day late and we can both tell.

 

[t_spacemonkey]

I give my wife .02-03ml of 200 test injection twice per week. For her it's just the right mix. A day late and we can both tell.

nice, yeah this seems the sweet spot for many

 

[Belekas]

We've been experimenting with girls HRT for some time as well. Different situation and vibes. Tried different doses from basically 10-25mg/week. Was using Pharma Sustanon fwiw. Neither dose gave her libido which fucking sucks. Added E2 pills cuz shes deficient going through MP and she still feels nothing just a bit more energy. 1mg of E2 showed nothing at blood test but we need to test E2 sooner due to shorter half-life. Tried 2mg- still nothing. She got testogel prescribed so we tried some on top and she noticed slight virilization on face mustash area so we stopped injections as well as she was still on 25mg/week of Sustanon. We held different protocols for at least 12 weeks before blood test and evaluation. I can pull her bloodwork but don't want to derail thread. Now shes back on Testogel 2.5mg/day (1/10th of sachet) and will see what happens. Her libido has been dead pretty much since she lost her parents in early 20s and was trapped in a toxic relationship for the next 20 years or so. After all the experiments we've done we don't expect anything anymore. It is what it is. Hope you find the perfect dose and relief for your lady. Best of luck.

 

[FunkOdyssey]

E2 pills

These increase clotting risk and are not very effective. You want estradiol injections if you can get them, or failing that, transdermal E2.

If you can't find a doctor to play ball, the trans community is an excellent source for high quality UGL estradiol in many countries.

Don't supplement E2 without progesterone or you can cause endometrial thickening / cancer. Make sure endometrial thickness is being monitored periodically.

 

[Belekas]

These increase clotting risk and are not very effective. You want estradiol injections if you can get them, or failing that, transdermal E2.

Yeah but no way to get them in the UK via prescription and won't go private and not even sure they can help here so unless we buy online theres no other way to get that. We tried e2 gel, spray, pills- no bueno. Pretty much she feels absolutely fuck all. All the other bloods great and in great shape, eating good, training a bit and doing long walks with me so that side is covered. Frustrating af.

 

[FunkOdyssey]

Yeah but no way to get them in the UK

There's always a way.

Injections - HRT Cafe

HRTCafe.net, formerly DIYHRT.Cafe, is a website created to provide information for how to safely obtain DIY HRT for trans people who cannot access it via traditional means.

hrtcafe.net

 

[Belekas]

These increase clotting risk and are not very effective. You want estradiol injections if you can get them, or failing that, transdermal E2.

If you can't find a doctor to play ball, the trans community is an excellent source for high quality UGL estradiol in many countries.

Don't supplement E2 without progesterone or you can cause endometrial thickening / cancer. Make sure endothelial thickness is being monitored periodically.

Yeah i know all this but thanks mate appreciate it. Shes being monitored and we being proactive so all that covered just that nothing works. I'm actually surprised myself that nothing moved the needle for her.

 

[Belekas]

There's always a way.

Injections - HRT Cafe

HRTCafe.net, formerly DIYHRT.Cafe, is a website created to provide information for how to safely obtain DIY HRT for trans people who cannot access it via traditional means.

hrtcafe.net

Nice. Will look into getting it probably after Xmas. Thank you!

 

[FunkOdyssey]

I'm actually surprised myself that nothing moved the needle for her.

For many women, estradiol doesn't help until you reach 200+ pg/ml - lesser administration methods and mainstream docs will rarely get you there. Beware of elevated SHBG, which increases the total E2 they need to feel good, just like testosterone.

 

[Belekas]

For many women, estradiol doesn't help until you reach 200+ pg/ml - lesser administration methods and mainstream docs will rarely get you there. Beware of elevated SHBG, which increases the total E2 they need to feel good, just like testosterone.

Would you recommend enanthate or valerate or cypionate? Too many choices and I haven't studied them yet but I will now that you shares a source. Her e2 when measured at through was 88 pmol/L after 1mg e2 pill testing next day early morning so that's pretty much nothing at all considering her baseline is the same iirc.

 

[FunkOdyssey]

Would you recommend enanthate or valerate or cypionate?

Cypionate or enanthate. We started with E3.5D but had better results with EOD cypionate.

 

[Belekas]

Cypionate or enanthate. We started with E3.5D but had better results with EOD cypionate.

Got it. Do you think theres still possibility that even injectable doesn't raise her e2 or thats not possible at all? We tried gel, spray, patches and pills. So only injections left at this point. Also what dose shes on and what levels does blood test show?

 

[FunkOdyssey]

Do you think theres still possibility that even injectable doesn't raise her e2 or thats not possible at all?

No, it's not possible that injections will fail to raise her levels. If you inject subq, maybe a percentage is lost to the void like sometimes happens with test, but in that case you just inject more. The levels will come up.

Also what dose shes on and what levels does blood test show?

1.2 mg estradiol cypionate EOD, 299 pg/ml total E2, 3.56 pg/ml free E2 (equilibrium dialysis). She has quite high SHBG so the total e2 needs to be that high for a decent free E2.

 

[Belekas]

No, it's not possible that injections will fail to raise her levels. If you inject subq, maybe a percentage is lost to the void like sometimes happens with test, but in that case you just inject more. The levels will come up.



1.2 mg estradiol cypionate EOD, 299 pg/ml total E2, 3.56 pg/ml free E2 (equilibrium dialysis). She has quite high SHBG so the total e2 needs to be that high for a decent free E2.

Ok understood, cool. My girls shbg before all the experiments when we tested was high 158 nmol/L. With decent T dose we get it close to 100. And with 25mg at week, obv too much, we had 81.4 nmol/L fwiw. Will see what Testogel does and how bloods look when its time. Will try getting this injectable e2 now asap cuz this is taking too long. Way too long.

 

[Guided_by_Voices]

Ok understood, cool. My girls shbg before all the experiments when we tested was high 158 nmol/L. With decent T dose we get it close to 100. And with 25mg at week, obv too much, we had 81.4 nmol/L fwiw. Will see what Testogel does and how bloods look when its time. Will try getting this injectable e2 now asap cuz this is taking too long. Way too long.

I apologize if you covered this elsewhere, but have you tried a small dose (e.g. 3mg) of Oxandrolone and/or DHEA? I have heard many reports of Oxandrolone helping women's libido.

 

[Belekas]

I apologize if you covered this elsewhere, but have you tried a small dose (e.g. 3mg) of Oxandrolone and/or DHEA? I have heard many reports of Oxandrolone helping women's libido.

Hi GBV. Hope all is well. And no, we haven't tried any of those yet. Last 2 years we have been trying to raise her e2 using gels, sprays, patches, pills which all failed tremendously. Libido is not my main task, raising her chronically nuked e2 is and what will come with it will be a bonus. Shes 50 and been very low e2 probably half her life which is fucking brutal and detrimental. We have everything covered by the NHS and basically get all the moving parts for free yet nothing worked and we are frustrated af. Worn out and tired from all this not even talking about her terrible e2 symptoms. Shes sad that these 2 years we didn't manage to move the needle into right direction just know now that all this crap we tried did pretty much nothing for her e2. T didn't bring anything else just some energy no matter what dose 5-25mg/week. She has high natural total t but nuked free t and high 150s shbg fwiw. So yeah seems the only way to sort this is to buy injectable e2 and get the ball rolling asap. Your mentioned stuff is also very interesting but after 2 years non-stop experimenting, logging, thinking and shit shes burned out but still willing to explore further things down the line.