Old drug does it cure cancer?

Vince

Super Moderator
An inexpensive drug already in use for other diseases might hold the key to a completely new way of treating cancers – not by killing off cancer cells, but by simply reprogramming them.

These findings come from exciting Canadian research on patients with brain tumours. The study revealed that DCA – or sodium dichloroacetate – can shrink the tumors by altering the cancer cell’s metabolism. While the study was small, only five patients, the researchers say their findings are “proof in principle” that this treatment approach works.

However, since DCA is a generic drug, no big pharmaceutical companies can claim exclusivity over the potential sales if they decide to fund further studies on cancer. The only remaining option to continue researching its potential place in oncology remains within the universities, health authorities and the support of funding agencies.

“That was the biggest challenge in the beginning: no industry support, no clinical applications,” explained Dr. Evangelos Michelakis.

Nevertheless, with the generous support of potential donors and the work of the scientific community, anything can happen.

 
Speaking of old drugs and cancer......



 
An inexpensive drug already in use for other diseases might hold the key to a completely new way of treating cancers – not by killing off cancer cells, but by simply reprogramming them.

These findings come from exciting Canadian research on patients with brain tumours. The study revealed that DCA – or sodium dichloroacetate – can shrink the tumors by altering the cancer cell’s metabolism. While the study was small, only five patients, the researchers say their findings are “proof in principle” that this treatment approach works.

However, since DCA is a generic drug, no big pharmaceutical companies can claim exclusivity over the potential sales if they decide to fund further studies on cancer. The only remaining option to continue researching its potential place in oncology remains within the universities, health authorities and the support of funding agencies.

“That was the biggest challenge in the beginning: no industry support, no clinical applications,” explained Dr. Evangelos Michelakis.

Nevertheless, with the generous support of potential donors and the work of the scientific community, anything can happen.

Sad that it always boils down to money
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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