I like your post and it's really helpful,
I agree GA,
Labs are important but only take a snapshot from one moment in time as estrogen fluctuates.
For me erectile strength (morning wood) is the best indication of where my e2 is at.
I'm on 100mg twice a week and .25mg anastrozole 24-36 hours post injection.
The worst part about the Adex is cutting those pills... never exact... nor is the liquid dosing.
I was running 50eod for a while TT was 1270... Free t thru the roof... e2 37... but still didn't feel great. E2 was too high despite a good ratio.
I'm very sensitive to estrogen and very sensitive to anastrozole. Sometimes a very difficult balancing act... still way better than pre-TRT.
I feel best when e2 is high teens believe it or not.
I am low shbg.
So what do you do?
Low shbg guys have had success with more frequent injections... but (for me) does not eliminate the need for AI.
The most success I have had is a steady t protocol and gauge e2 by morning wood then come close to establishing a protocol although it always varies and cutting those pills sucks.
For my low SHBG im trying an E2 in the <20 range, I was using .25mg/EOD that took me to the teens and we thought that that was too low so we went .25 M/W/F, but we didn't take in to account some of this new(er) info about low SHBG and Free Estrogen that goes along with High Free T that we low SHBG guys have. SO it's something that is a newer viewpoint for the low SHBG crowd.
please explain this Free Estrogen and Free Testosterone relationship with low SHBG guys, cause I did noticed doing better with my E2 on the low side, like around 25, is that free Estrogen binds to FT giving us a false high FT reading??