Testosterone Replacement Therapy (TRT) Decreases Ferritin

Nelson Vergel

Founder, ExcelMale.com
Testosterone replacement can cause a decrease in ferritin in men even without the presence or use of blood donations or therapeutic phlebotomies. A study gave men testosterone enanthate at a dose of 125 mg per week (it also used T enanthate with or without finasteride to see the effect of blocking 5 alpha reductase while on TRT). These are the ferritin values after 3 months. Ferritin was reduced at an average of 32% within 3 months of treatment initiation without altering iron, transferrin, or transferrin saturation.

decreased ferritin with TRT.jpg

Source: Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone

Last edited:

Nelson Vergel

Founder, ExcelMale.com



Active Member
This is interesting. I would assume those of who frequently give blood on TRT to manage hematocrit are particularly vulnerable to low ferritin.

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